Design, synthesis and biological evaluation of certain 4-(Piperazin-1-yl)quinoline derivatives / Mohamed Farouk Ali Hamissa ; Supervised Mohamed Nabil Youssef Aboulenein , Fatma Abdelfattah Ragab

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Chemistry

The search for antitumour compounds with selective activity and less toxicity continue to be an area of intensive research in medicinal chemistry. Thus, this work deals with the synthesis of certain 4-(piperazin-1-yl)quinoline derivatives IVa-t with the aim to evaluate their anticancer properties. The thesis consists of the following sections: Introduction: This part includes a review on the different biological activities of 7-chloro-4-(piperazin-1-yl)quinoline derivatives. Basis of the present investigations: This section discusses the rationale on which the design of synthesized compounds was based in addition to the schemes followed in their synthesis. Theoretical discussion: This section addresses the reactions followed in the synthesis of the new target compounds IVa-t in addition to the needed intermediates III, VIp-t, VIIp-t and VIIIo-t and their preparation. Scheme 1 described the strategies followed for the synthesis of the designed compounds, as well as starting materials and intermediates. Biological evaluation: The above mentioned synthesized compounds III and IVa-t were tested for their cytotoxic effect against breast (MCF-7) and prostate (PC3) cancer cell lines. The achieved biological results and structure activity relationship of the studied compounds were discussed

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