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Effects of metformin on serum insulin, anti - mullerian hormone and on androgen levels in patients with polycystic ovarian syndrome / Zamzam Ahmed Dawoud ; Supervised Omar Abdelaziz Mohamed , Manal Mohamed Kamal , Sherif Adel Dahab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Zamzam Ahmed Dawoud , 2015Description: 113 Leaves : charts ; 25cmOther title:
  • تاثير المتفورمين على مستويات الانسولين و هرمون المضاد للموليريان و هرمونات الذكورة فى المصل فى مرضى متلازمة تكيس المبيض [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics Summary: Evaluate the effect of metformin on serum insulin (fasting and 2hr postprandial), androgens (total and free testosterone, DHEAS and SHBG) and AMH in PCOS patients at 3 and 6 months interval. Prospective study. Kasr Alaini university hospital, obstetrics and gynecology department. 50 hyperandrogenic PCOS patients. Interventions: 1700 mg metformin was given for a period of 6 months; serum insulin, previously mentioned androgens and AMH were measured at baseline, 3 months and 6 months of treatment. Serum fasting and 2 hrs. postprandial insulin and glucose levels, insulin resistance, serum total and free testosterone, DHEAS and SHBG and serum AMH. The impact of treatment and biochemical changes on menstrual regularity, clinical manifestations of hyperandrogenism, ovarian morphology and fertility. Effects of Metformin on serum Insulin, anti - mullerian hormone and on androgen levels in patients with PCOS viii. Metformin treatment produced a significant reduction in insulin, serum androgens and AMH levels. 62% of the patients had improvement in their cycle regularity and 2 out of 50 patients had spontaneous pregnancy. However, there were no improvement in hyperandrogenic manifestations or change in ovarian morphology. Metformin as an insulin sensitizing agent improved insulin resistance in PCOS patients and improved biochemical but not clinical hyperandrogenism. Metformin produced significant reduction in AMH levels and modest improvement in cycle regularity; but no change in the ovarian morphology. Metformin could not be used for the treatment of hirsutism or in improving fertility in PCOS
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.15.Ph.D.2015.Za.E (Browse shelf(Opens below)) Not for loan 01010110068717000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.15.Ph.D.2015.Za.E (Browse shelf(Opens below)) 68717.CD Not for loan 01020110068717000
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Cai01.11.15.Ph.D.2015.Ta.S Sonographic assessment of myometrial thickness as a predictor for the latency interval in women with preterm premature rupture of membranes and oligohydramnios / Cai01.11.15.Ph.D.2015.Ta.S Sonographic assessment of myometrial thickness as a predictor for the latency interval in women with preterm premature rupture of membranes and oligohydramnios / Cai01.11.15.Ph.D.2015.Za.E Effects of metformin on serum insulin, anti - mullerian hormone and on androgen levels in patients with polycystic ovarian syndrome / Cai01.11.15.Ph.D.2015.Za.E Effects of metformin on serum insulin, anti - mullerian hormone and on androgen levels in patients with polycystic ovarian syndrome / Cai01.11.15.Ph.D.2016.Ah.H Histomorphology of the placenta and the placental bed of severe preeclamptic patients complicated by Growth restricted fetuses and correlation with the doppler velocimetries of the uterine and umbilical arteries / Cai01.11.15.Ph.D.2016.Ah.H Histomorphology of the placenta and the placental bed of severe preeclamptic patients complicated by Growth restricted fetuses and correlation with the doppler velocimetries of the uterine and umbilical arteries / Cai01.11.15.Ph.D.2016.Ba.B Body mass index, modified bishop score and transvaginal sonographic measurment of cervical length as predictors of successful labour induction by misoprostol /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics

Evaluate the effect of metformin on serum insulin (fasting and 2hr postprandial), androgens (total and free testosterone, DHEAS and SHBG) and AMH in PCOS patients at 3 and 6 months interval. Prospective study. Kasr Alaini university hospital, obstetrics and gynecology department. 50 hyperandrogenic PCOS patients. Interventions: 1700 mg metformin was given for a period of 6 months; serum insulin, previously mentioned androgens and AMH were measured at baseline, 3 months and 6 months of treatment. Serum fasting and 2 hrs. postprandial insulin and glucose levels, insulin resistance, serum total and free testosterone, DHEAS and SHBG and serum AMH. The impact of treatment and biochemical changes on menstrual regularity, clinical manifestations of hyperandrogenism, ovarian morphology and fertility. Effects of Metformin on serum Insulin, anti - mullerian hormone and on androgen levels in patients with PCOS viii. Metformin treatment produced a significant reduction in insulin, serum androgens and AMH levels. 62% of the patients had improvement in their cycle regularity and 2 out of 50 patients had spontaneous pregnancy. However, there were no improvement in hyperandrogenic manifestations or change in ovarian morphology. Metformin as an insulin sensitizing agent improved insulin resistance in PCOS patients and improved biochemical but not clinical hyperandrogenism. Metformin produced significant reduction in AMH levels and modest improvement in cycle regularity; but no change in the ovarian morphology. Metformin could not be used for the treatment of hirsutism or in improving fertility in PCOS

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