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Study of the possible effects of an angiotensin II - receptor antagonist in experimentally induced renal injury associated with gastric ulcer in rats : Possible modulation by certain natural products / Mahmoud Ahmed Nour Eldin Mohamed ; Supervised Sanaa A. Kenawy , Azza Sayed M. Awad , Hesham A. Salem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mahmoud Ahmed Nour Eldin Mohamed , 2015Description: 284 P. : charts , facsimiles ; 25cmOther title:
  • دراسة التأثيرات المحتملة لواحد من غالقات مستقبلات أنجيوتنسين الثانى فى الضرر الكلوى المصحوب بقرحة فى المعدة و المستحدث تجريبيا فى الجرذان و امكانية تعديل التغيرات المحدثة ببعض المنتجات الطبيعية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Effect of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) on glycerol induced ARF associated with gastric ulcer.1) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) improved the impairment of renal functions through the significant reduction in S Cr, BUN, UTP, Kw/Bw ratio and increase in creatinine clearance as compared to R.F+GU group. 2) Administration of telmisartan (10mg / kg), TQ (10mg / kg), and Ý glucan (80mg / kg) improved the impairment of renal functions through the significant reduction of potassium level as compared to R.F + GU group. 3) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) improved the gastric ulcer through the significant reduction in gastric ulcer, gastric index, biochemical and histopathological examination. 4) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) as protective offered a nephroprotective and gastroprotective effect compared to RF + GU group, as manifested by a significant attenuation of lipid peroxidation as evident by decreased renal and gastric TBARs contents and protected against severe depletion of the anti oxidant enzyme pool as evident by increased renal and gastric GSH contents and increase SOD activity, associated with a significant increase in kidney and gastric tissue NO3- / NO2- content as compared to R.F + GU group. 5) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) significantly decrease TNF Ü content, MPO activity and caspase 3 activity as compared to R.F + GU group. 6) The histopathological changes shown had confirmed the biochemical changes recorded in the present investigation
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2015.Ma.S (Browse shelf(Opens below)) Not for loan 01010110068734000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2015.Ma.S (Browse shelf(Opens below)) 68734.CD Not for loan 01020110068734000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Effect of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) on glycerol induced ARF associated with gastric ulcer.1) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) improved the impairment of renal functions through the significant reduction in S Cr, BUN, UTP, Kw/Bw ratio and increase in creatinine clearance as compared to R.F+GU group. 2) Administration of telmisartan (10mg / kg), TQ (10mg / kg), and Ý glucan (80mg / kg) improved the impairment of renal functions through the significant reduction of potassium level as compared to R.F + GU group. 3) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) improved the gastric ulcer through the significant reduction in gastric ulcer, gastric index, biochemical and histopathological examination. 4) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) as protective offered a nephroprotective and gastroprotective effect compared to RF + GU group, as manifested by a significant attenuation of lipid peroxidation as evident by decreased renal and gastric TBARs contents and protected against severe depletion of the anti oxidant enzyme pool as evident by increased renal and gastric GSH contents and increase SOD activity, associated with a significant increase in kidney and gastric tissue NO3- / NO2- content as compared to R.F + GU group. 5) Administration of telmisartan (10mg / kg), TQ (10mg / kg), Ý glucan (80mg / kg) and parsley (600mg / kg) significantly decrease TNF Ü content, MPO activity and caspase 3 activity as compared to R.F + GU group. 6) The histopathological changes shown had confirmed the biochemical changes recorded in the present investigation

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