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Relation between BRCA-IRIS expression in metastatic breast cancer and different clinico-pathological factors / Mostafa Mohammed Abdelhafeez ; Supervised Abeer Ahmed Bahnassy , Ayman Abdelsamea Gaber , Mohammed Ghareeb Mahmoud

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mostafa Mohammed Abdelhafeez , 2015Description: 113 P. : charts , facsimiles ; 25cmOther title:
  • فى حالات سرطان الثدى ذو الثنائيات والعوامل الإكلينيكية والباثولوجية BRCA-IRIS العلاقة بين وجود الجين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Medical) Summary: Introduction: Breast cancer is the most common cancer and the highest cause of cancer mortality in women worldwide. Objective: This study{u2019}s aim was to find the relation between expression of BRCA-IRIS gene in patients with metastatic breast cancer and the different correlated clinical and pathological characters of the disease. Methods: This study follows metastatic breast cancer patients with available paraffin blocks during the year 2010 in the National Cancer Institute of Egypt. Results: The study included (60) Egyptian female patients. The mean age of the subjects was 48.4 years. Of the patients, 32 show overexpression of BRCA-IRIS gene and 28 patients show normal expression of BRCA-IRIS gene; HER2 and PFS were the only statistically significant correlated factors to BRCA-IRIS overexpression. Conclusion: BRCA-IRIS gene overexpression is a poor prognostic factor and triggers aggressive breast tumor formation
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.M.Sc.2015.Mo.R (Browse shelf(Opens below)) Not for loan 01010110068696000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.M.Sc.2015.Mo.R (Browse shelf(Opens below)) 68696.CD Not for loan 01020110068696000

Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Medical)

Introduction: Breast cancer is the most common cancer and the highest cause of cancer mortality in women worldwide. Objective: This study{u2019}s aim was to find the relation between expression of BRCA-IRIS gene in patients with metastatic breast cancer and the different correlated clinical and pathological characters of the disease. Methods: This study follows metastatic breast cancer patients with available paraffin blocks during the year 2010 in the National Cancer Institute of Egypt. Results: The study included (60) Egyptian female patients. The mean age of the subjects was 48.4 years. Of the patients, 32 show overexpression of BRCA-IRIS gene and 28 patients show normal expression of BRCA-IRIS gene; HER2 and PFS were the only statistically significant correlated factors to BRCA-IRIS overexpression. Conclusion: BRCA-IRIS gene overexpression is a poor prognostic factor and triggers aggressive breast tumor formation

Issued also as CD

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