Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

Nanobacteria are unusual agents 100 fold smaller than common bacteria that can replicate apatite forming units. They are the smallest cell-walled bacteria, only recently discovered in human and cow blood and in commercial cell culture serum. Recent evidence suggests a role for nanobacteria in a number of human diseases, especially renal stone formation. The present study is conducted to identify the chemical compositions of nine essential oils from some edible plants and to elucidate the nephroprotective activities of these oils against nanobacterial infection to lower the incidence of many hazard health problems in human and animals to avoid the existence diseases by these bacteria. Fifteen compounds were identified for each of tested oil by GC / MS analysis. Among all tested essential oils, sage, nutmeg, lemon, apricot and strawberry had in vitro anti nanobacterial activity. Only, sage oil was found to be highly bacteriostatic at 125 æg ml 1 and bactericidal at 250 æg ml 1. They prevented the nanobacterial nephrotoxicity as evidenced by significantly reduced levels of serum urea and creatinine and prevented the renal tissues from severe pathological changes

Issued also as CD