Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

The aim of this study was to investigate the effect of non surgical periodontal therapy on GCF level of Visfatin in patients with moderate chronic periodontitis. The purpose of the present study was to assess the level of visfatin in samples of GCF from chronic periodontitis patients before and after scaling and root planing (SRP).The study included 30 patients divided into two groups: Group I: consisted 20 patients with chronic periodontitis treated by scaling and root planing.Group II: the control group which consisted of ten healthy individuals.Clinical parameters including gingival index, plaque index, pocket depth and clinical attachment level were measured and GCF samples were collected using paper points for each patient at baseline for both groups and 4 weeks after treatment by (SRP) for group I only. Visfatin detection in GCF was performed using a commercial ELISA kit. The results of the present study revealed that the highest levels of Visfatin concentrations in GCF were obtained in chronic periodontitis group I and the least levels were found in the control group II with a statistically significant difference between them. Visfatin levels in GCF decreased in chronic periodontitis group after treatment, yet it's level was still higher than that of the control group. Visfatincould be used as a marker for the periodontal disease activity and outcome of periodontal therapy

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