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Thyroid hormones and leptin status in Egyptian obese children / Aya Ahmed Ayman ; Supervised Amira A. Shaheen , Awatif M. Abdelmaksoud , Hebatallah A. Darwish

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Aya Ahmed Ayman , 2015Description: 135 P. : facsimiles ; 25cmOther title:
  • حالة هرمونات الغدة الدرقية والليبتين في الأطفال المصريين المصابين بالبدانة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Childhood obesity is one of the most serious public health problems facing the developed and increasingly, the developing world. In this study, we aimed to investigate the possible role of thyroid hormones and some adipocytokines in childhood obesity. A total of 80 children were enrolled; 50 obese children and 30 non-obese of matched age and sex. Clinical, demographic characteristics and lipid profile levels were monitored. Plasma levels of thyroid hormones (Thyroid stimulating hormone; TSH, thyroxine; T4 and triiodothyronine; T3), leptin, interleukin 1- alpha (IL1-Ü) and tumor necrosis factor- alpha (TNF-Ü), as well as urinary iodine were measured in these subjects. Dyslipidemia, in terms of increased total cholesterol (T.ch), low density lipoprotein- cholesterol (LDL-c) and triglycerides (TG) levels along with decreased high density lipoprotein- cholesterol (HDL-c) levels, was evident in obese children relative to normal ones. Obese children exhibited a significant reduction in TSH and free- T4 levels. Meanwhile, the levels of total- T3, free- T3 and urinary iodine output were insignificantly changed. There was an increment in both leptin and IL1-Ü levels of obese children, however, their TNF-Ü levels were significantly decreased. Alterations in thyroid hormones status, leptin, IL1-Ü and TNF-Ü might be implicated in the etiology of obesity associated with Egyptian children
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.Ay.T (Browse shelf(Opens below)) Not for loan 01010110068793000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.Ay.T (Browse shelf(Opens below)) 68793.CD Not for loan 01020110068793000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Childhood obesity is one of the most serious public health problems facing the developed and increasingly, the developing world. In this study, we aimed to investigate the possible role of thyroid hormones and some adipocytokines in childhood obesity. A total of 80 children were enrolled; 50 obese children and 30 non-obese of matched age and sex. Clinical, demographic characteristics and lipid profile levels were monitored. Plasma levels of thyroid hormones (Thyroid stimulating hormone; TSH, thyroxine; T4 and triiodothyronine; T3), leptin, interleukin 1- alpha (IL1-Ü) and tumor necrosis factor- alpha (TNF-Ü), as well as urinary iodine were measured in these subjects. Dyslipidemia, in terms of increased total cholesterol (T.ch), low density lipoprotein- cholesterol (LDL-c) and triglycerides (TG) levels along with decreased high density lipoprotein- cholesterol (HDL-c) levels, was evident in obese children relative to normal ones. Obese children exhibited a significant reduction in TSH and free- T4 levels. Meanwhile, the levels of total- T3, free- T3 and urinary iodine output were insignificantly changed. There was an increment in both leptin and IL1-Ü levels of obese children, however, their TNF-Ü levels were significantly decreased. Alterations in thyroid hormones status, leptin, IL1-Ü and TNF-Ü might be implicated in the etiology of obesity associated with Egyptian children

Issued also as CD

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