Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

In the present case- control study, detection of Angiotensin Converting Enzyme (ACE) Polymorphism among admitted children suffering from community-acquired pneumonia (CAP) was performed to investigate the associationbetweenACE polymorphismand the risk and outcome of CAP. The study was conducted on 77 children with CAP and 73 healthy age- and sex- matched controls. Cases were subjected to a complete clinical study and investigations were performed: Complete Blood Count (CBC), chest x- ray (CXR), C - reactive protein (CRP), Erythrocytic Sedimentation Rate (ESR) in the first hour, and Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) Polymorphism using polymerase chain reaction (PCR). The study yielded the following results:The present study couldn{u2019}t demonstrate a significant association between different types of ACE genotypes of ACE polymorphism in relation to pneumonia risk(P value >0.05).There was no statistically significant association between different genotypes of ACE polymorphismin pneumonia patients and outcome of pneumonia (oxygen need, ICU admission, need for mechanical ventilation, death & hospital stay more than 1 week) (P value >0.05). The study concludes that ACE polymorphismhas no significant relation to risk & outcome of pediatric pneumonia. Therefore, further studies in this topic should be conducted

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