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Carboplatin/gemcitabine as first line treatment of metastatic triple negative breast cancer / Ahmad Mahrous Dewidar ; Supervised Mohammad Ahmad Hassan , Mohammad Sayed Abdelkader , Wael Samir Makar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmad Mahrous Dewidar , 2015Description: 72 P. : charts , facsimiles ; 25cmOther title:
  • علاج سرطان الثدي السلبي الثلاثي المنتشر باستخدام عقاري الجيمسيتابين/كاربوبلاتين كخط علاج أول [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Oncology (clinical) Summary: Background and objectives: Triple-negative breast cancer is regarded as an aggressive disease for which effective targeted therapy is not yet available. Results: Among the 34 included patients , 33 were considered valuable for response as one patient refused to continue treatment after she received the first week of treatment due to grade 3 vomiting, four patients (12.1%) achieved complete response and 20 patients (60.6%) had a partial response giving an overall response rate of 72.7% (95% CI, 60%-84%), one patients(3%) had stable disease > 6 months giving clinical benefit rate(CBR) of 75.7% (25/٣٣). The median duration of response of 6.5 months. while 8 cases progressed in treatment (24.7%), Median progression-free survival, was 6.18 months (95% CI 5.61{u2013}7·30 ) .Overall survival was 12.7month (range2-24, SD: 5.1) . Neutropenia G3 in 3 patients(9%) one of them developed febrile neutropenia ,anemia grade three in 4\33 patients(12%), thrombocytopenia grade 3 in 5 patinets (15%). Conclusions:. This study suggested that The combination was efficacious and well tolerated  
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.Ph.D.2015.Ah.C (Browse shelf(Opens below)) Not for loan 01010110068873000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.Ph.D.2015.Ah.C (Browse shelf(Opens below)) 68873.CD Not for loan 01020110068873000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Oncology (clinical)

Background and objectives: Triple-negative breast cancer is regarded as an aggressive disease for which effective targeted therapy is not yet available. Results: Among the 34 included patients , 33 were considered valuable for response as one patient refused to continue treatment after she received the first week of treatment due to grade 3 vomiting, four patients (12.1%) achieved complete response and 20 patients (60.6%) had a partial response giving an overall response rate of 72.7% (95% CI, 60%-84%), one patients(3%) had stable disease > 6 months giving clinical benefit rate(CBR) of 75.7% (25/٣٣). The median duration of response of 6.5 months. while 8 cases progressed in treatment (24.7%), Median progression-free survival, was 6.18 months (95% CI 5.61{u2013}7·30 ) .Overall survival was 12.7month (range2-24, SD: 5.1) . Neutropenia G3 in 3 patients(9%) one of them developed febrile neutropenia ,anemia grade three in 4\33 patients(12%), thrombocytopenia grade 3 in 5 patinets (15%). Conclusions:. This study suggested that The combination was efficacious and well tolerated  

Issued also as CD

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