New approaches for the synthesis of thiophenes, pyrans, azoles and azines derivatives and their antitumor evaluation / Noha Alsaghir Mousa Ahmed ; Supervised Hamdi Hassaneen , Rafat Mohareb

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Noha Alsaghir Mousa Ahmed

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TextLanguage: English Publication details: Cairo : Noha Alsaghir Mousa Ahmed , 2015Description: 133 P. ; 25cmOther title:

اتجاهات جديدة لتحضير مشتقات الثيوفينات: البيران: الأزول و الأزينات و تقييمها كمضادات للأورام [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: This research aims to novel synthesis of thiophene, pyrans, azoles and azines derivatives in which we started with cyclopentanone as starting material which reacted with malononitrile and ethylcyanoacetate. The synthesized compounds were confirmed with spectral and analytical analysis. The biological evaluation of compounds are tested on three different tumor cell lines such as breast adenocarcinoma, CNS cancer and non small lung cancer and were compared to the inhibitory effect of doxorubicin. And the results revealed that compounds 7, 13b and 17b have the highest inhibitory effect

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.10.M.Sc.2015.No.N (Browse shelf(Opens below))		Not for loan	01010110068941000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.10.M.Sc.2015.No.N (Browse shelf(Opens below))	68941.CD	Not for loan	01020110068941000

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Previous	Cai01.12.10.M.Sc.2015.No.H Heteroarylnitrilimines and related intermediates in the synthesis of heterocyclic compounds with expected biological activity /	Cai01.12.10.M.Sc.2015.No.N New approaches for the uses of active methylene reagents for the synthesis of pharmaceutically active heterocyclic compounds /	Cai01.12.10.M.Sc.2015.No.N New approaches for the uses of active methylene reagents for the synthesis of pharmaceutically active heterocyclic compounds /	Cai01.12.10.M.Sc.2015.No.N New approaches for the synthesis of thiophenes, pyrans, azoles and azines derivatives and their antitumor evaluation /	Cai01.12.10.M.Sc.2015.No.N New approaches for the synthesis of thiophenes, pyrans, azoles and azines derivatives and their antitumor evaluation /	Cai01.12.10.M.Sc.2015.Os.S Synthesis of novel bis-heterocycles of expected useful applications /	Cai01.12.10.M.Sc.2015.Os.S Synthesis of novel bis-heterocycles of expected useful applications /	Next

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

This research aims to novel synthesis of thiophene, pyrans, azoles and azines derivatives in which we started with cyclopentanone as starting material which reacted with malononitrile and ethylcyanoacetate. The synthesized compounds were confirmed with spectral and analytical analysis. The biological evaluation of compounds are tested on three different tumor cell lines such as breast adenocarcinoma, CNS cancer and non small lung cancer and were compared to the inhibitory effect of doxorubicin. And the results revealed that compounds 7, 13b and 17b have the highest inhibitory effect

Issued also as CD

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