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Evaluation of potential protective role of different stages of echinostoma liei antigens against schistosoma mansoni in mice / Ghada Abdelmonem Ismaiel Zhran ; Supervised Azza Mohamed Elamir , Alyaa Ahmed Farid , Hoda Yakoup

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ghada Abdelmonem Ismaiel Zhran , 2015Description: 100 Leaves : charts ; 25cmOther title:
  • {uFEBF}{uFEAA} ا{uئإؤئ}{uئإ٩٢}{uئإإ٠}{uئإإأ}{uئإ٨إ}ر{uئإآ٣}{uئإئ٤}{uئإ٨إ} ا{uئإؤئ}{uئإإ٤}{uئإأأ}{uئإإإ}{uئإئ٣}{uئإإء} فى ا{uئإؤئ}{uئإؤ٤}ئران ا{uئإؤئ}{uئإآأ}{uئإؤ٠}{uئإئ٤}{uئإءإ}{uئإإ٩} Echinostoma liei {uFE97}{uFED8}{uFEF4}{uFEF4}{uFEE2} دو ا{uئإؤئ}{uئإء٤}{uئإإ٤}{uئإ٨إ}{uئإئ٣}{uئإإء} ا{uئإؤئ}{uئإؤ٤}{uئإأأ}{uئإ٨إ}{uئإؤئ}{uئإإء} {uئإئ٧}{uئإإ٧}{uئإ٩٨}{uئإئ٤}{uئإء٠}{uئإئ٤}{uئإإ٨}{uئإ٨إ}ت ا{uئإؤئ}{uئإإ٤}{uئإءإ}ا{uئإء٣}{uئإؤإ} ا{uئإؤئ}{uئإإ٤}{uئإء٨}{uئإ٩٨}{uئإإ٠}{uئإؤ٤}{uئإإء} {uئإإ٣}{uئإإ٦} [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology Summary: The effect of immunization protocol against S. mansoni infection with purified antigens from E. liei on resistance to S. mansoni infection and associated immunoparasitological changes in murine experimental model was studied. High significant reduction in worm burden, hepatic and intestinal tissue egg loads were observed on comparing the immunized groups with the infected control group (P > 0.001). The results showed an alteration in the Egg deposition, reduction in MGN, MGD amount of hepatic fibrosis, interference with granuloma maturation and cytokine secretion level. Results revealed that immunization with E. liei worm antigens stimulated IgG1, IgG2 and IgG4 secretion more than any other type of antigens. On the other hand, E. liei rediae antigens were more effective than other types in stimulating IgM secretion when compared to infected control group. In conclusion, our findings showed that multiple intraperitoneal adminestration of purified E. liei antigen induce highly significant reduction in worm burden, hepatic and intestinal tissue egg loads and granuloma size 8 weeks post infection
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2015.Gh.E (Browse shelf(Opens below)) Not for loan 01010110068942000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2015.Gh.E (Browse shelf(Opens below)) 68942.CD Not for loan 01020110068942000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology

The effect of immunization protocol against S. mansoni infection with purified antigens from E. liei on resistance to S. mansoni infection and associated immunoparasitological changes in murine experimental model was studied. High significant reduction in worm burden, hepatic and intestinal tissue egg loads were observed on comparing the immunized groups with the infected control group (P > 0.001). The results showed an alteration in the Egg deposition, reduction in MGN, MGD amount of hepatic fibrosis, interference with granuloma maturation and cytokine secretion level. Results revealed that immunization with E. liei worm antigens stimulated IgG1, IgG2 and IgG4 secretion more than any other type of antigens. On the other hand, E. liei rediae antigens were more effective than other types in stimulating IgM secretion when compared to infected control group. In conclusion, our findings showed that multiple intraperitoneal adminestration of purified E. liei antigen induce highly significant reduction in worm burden, hepatic and intestinal tissue egg loads and granuloma size 8 weeks post infection

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