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A systematic review of the value of serum biomarkers in the assessment of hepatic fibrosis in chronic hepatitis C patients in Egypt ; and reevaluation of the identified most promising biomarker by prospective study / Mohammad Shaaban Mahfouz ; Supervised Magdy Amin Elserafy , Maissa Elsaid Elraziky , Abdelmageed Mahfouz Kasem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammad Shaaban Mahfouz , 2015Description: 166 P. : charts ; 25cmOther title:
  • مراجعه منهجيه لقيمة الدلالات الحيويه بالدم فى تقييم تليف الكبد فى مرضى الالتهاب الكبدى الفيروسى سى المزمن بمصر واعادة تقييم الدلاله الحيويه الواعده المحدده بدراسه مستقبليه [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Hepatitis C accounts for a sizable proportion of cases of chronic liver disease, and cases of hepatocellular carcinoma and represents the most common indication for liver transplantation. Determining the presence or absence of significant fibrosis is essential in deciding protocol of management of patients infected with HCV, however liver biopsy is an invasive procedure with an occasional complications, for this reason, a non-invasive method for assessing hepatic fibrosis is needed.The aim of this study is to evaluate the diagnostic value of the non-invasive biomarkers by performing a systematic review and meta-analysis on relevant Egyptian research material, and then a practical study will be done on this biomarker aiming to further assess its effectiveness in the evaluation of liver fibrosis METHODS: Systematic review was done revealed 48 studies, meta-analysis was done on hyaluronic acid and APRI studies, then the routine laboratory tests derived from AST and Platelets as one of the promising non-invasive markers in diagnosing the degree of liver fibrosis in 150 Egyptian patients with chronic HCV was done.RESULTS:Meta-analysis revealed sensitivity and specificity of APRI in detecting significant fibrosis 68.1% and 72.3% respectively and 84% and 83% for detection of cirrhosis
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2015.Mo.S (Browse shelf(Opens below)) Not for loan 01010110069076000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2015.Mo.S (Browse shelf(Opens below)) 69076.CD Not for loan 01020110069076000
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Cai01.11.33.Ph.D.2015.Am.E Evaluation of Glypican 3 as a tumour marker for early diagnosis of hepatocellular carcinoma / Cai01.11.33.Ph.D.2015.Mo.O Obesity-related colorectal carcinoma through insulin resistance, insulin growth factor-1 (IGF-1) And IGF binding protein-3 (IGFBP-3) and their genetic polymorphism / Cai01.11.33.Ph.D.2015.Mo.O Obesity-related colorectal carcinoma through insulin resistance, insulin growth factor-1 (IGF-1) And IGF binding protein-3 (IGFBP-3) and their genetic polymorphism / Cai01.11.33.Ph.D.2015.Mo.S A systematic review of the value of serum biomarkers in the assessment of hepatic fibrosis in chronic hepatitis C patients in Egypt ; and reevaluation of the identified most promising biomarker by prospective study / Cai01.11.33.Ph.D.2015.Mo.S A systematic review of the value of serum biomarkers in the assessment of hepatic fibrosis in chronic hepatitis C patients in Egypt ; and reevaluation of the identified most promising biomarker by prospective study / Cai01.11.33.Ph.D.2015.Ra.P Peripheral blood DNA methylation markers for the early detection of colorectal carcinoma in the Egyptian population : A multicenter study / Cai01.11.33.Ph.D.2015.Ra.P Peripheral blood DNA methylation markers for the early detection of colorectal carcinoma in the Egyptian population : A multicenter study /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Hepatitis C accounts for a sizable proportion of cases of chronic liver disease, and cases of hepatocellular carcinoma and represents the most common indication for liver transplantation. Determining the presence or absence of significant fibrosis is essential in deciding protocol of management of patients infected with HCV, however liver biopsy is an invasive procedure with an occasional complications, for this reason, a non-invasive method for assessing hepatic fibrosis is needed.The aim of this study is to evaluate the diagnostic value of the non-invasive biomarkers by performing a systematic review and meta-analysis on relevant Egyptian research material, and then a practical study will be done on this biomarker aiming to further assess its effectiveness in the evaluation of liver fibrosis METHODS: Systematic review was done revealed 48 studies, meta-analysis was done on hyaluronic acid and APRI studies, then the routine laboratory tests derived from AST and Platelets as one of the promising non-invasive markers in diagnosing the degree of liver fibrosis in 150 Egyptian patients with chronic HCV was done.RESULTS:Meta-analysis revealed sensitivity and specificity of APRI in detecting significant fibrosis 68.1% and 72.3% respectively and 84% and 83% for detection of cirrhosis

Issued also as CD

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