header
Image from OpenLibrary

A Correlation study between development of FVIII inhibitors in hemophilia a patients and IL-10 gene polymorphism / Gehad Atef Abdelmaksoud Elsayed ; Supervised Hoda Sadek , Ilham Youssry , Somaia Abdelrahman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Gehad Atef Abdelmaksoud Elsayed , 2015Description: 150 P. : charts , facsimiles ; 25cmOther title:
  • دارسة العلاقة بين تكوين الاجسام المثبطة لعامل التجلط (8)مرضى الهيموفيميا (أ) والتعدد الشكلى لجين الانترلوكين (10 [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: The development of alloantibodies (inhibitors) against the transfused factor VIII in Hemophilia A patients is the most serious therapy complication. The pathophysiology of their formation is still unknown. Many cytokines, including interleukin-10 (IL-10), may play a role in the perpetuation of such complication. Aim of the Work: The aim of this study is to evaluate the influence of IL-10 gene polymorphism (1082G>A) on the development of FVIII inhibitors. Also, the effects of some treatment related risk factors on the formation of FVIII inhibitors in multi-transfused hemophilia A patients. Subjects and Methods: Fifty patients with moderate to severe hemophilia A were examined for the existence of FVIII inhibitors by Bethesda method. In addition, all the patients, as well as 50 age and sex matched apparently healthy subjects were genotyped for IL-10 gene polymorphisms (1082G>A) using polymerase chain reaction{u2013}restriction fragment length polymorphism (PCR-RFLP). Chi square test and Fisher{u2019}s exact test were used for statistical analysis
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Ge.C (Browse shelf(Opens below)) Not for loan 01010110069170000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Ge.C (Browse shelf(Opens below)) 69170.CD Not for loan 01020110069170000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: The development of alloantibodies (inhibitors) against the transfused factor VIII in Hemophilia A patients is the most serious therapy complication. The pathophysiology of their formation is still unknown. Many cytokines, including interleukin-10 (IL-10), may play a role in the perpetuation of such complication. Aim of the Work: The aim of this study is to evaluate the influence of IL-10 gene polymorphism (1082G>A) on the development of FVIII inhibitors. Also, the effects of some treatment related risk factors on the formation of FVIII inhibitors in multi-transfused hemophilia A patients. Subjects and Methods: Fifty patients with moderate to severe hemophilia A were examined for the existence of FVIII inhibitors by Bethesda method. In addition, all the patients, as well as 50 age and sex matched apparently healthy subjects were genotyped for IL-10 gene polymorphisms (1082G>A) using polymerase chain reaction{u2013}restriction fragment length polymorphism (PCR-RFLP). Chi square test and Fisher{u2019}s exact test were used for statistical analysis

Issued also as CD

There are no comments on this title.

to post a comment.