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Interferon-Þ and interleukin-10 gene polymorphisms as prognostic predictors In Hepatitis C Virus patients / May Mohamed Ahmed ; Supervised Nermine Ahmed Bahgat , Manal Mohamed Kamal , Mohamed Mahmoud Nabil

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : May Mohamed Ahmed , 2016Description: 138 P. : charts , facsimiles ; 25cmOther title:
  • التعدد فى الشكل الچيني لانترفيرون {u٢٠١٣} جاما وانترلوكين - {u٠٦ئ١}{u٠٦ئ٠} للتنبؤ بالتطور المرضى فى مرضى فيروس الالتهاب الكبدى -سى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: The aim of this work was to evaluate whether single nucleotide polymorphisms in interferon- gamma (IFN-Þ) (+874T/A) and interleukin-10 (IL-10) (-1082G/A) genes are associated with susceptibility and/or are markers of prognosis to chronic hepatitis C outcomes. Patients and methods: The study was performed on 100 participants; first group was formed of 25 non-cirrhotic patients with chronic hepatitis, and the second group (n=50) was formed of cirrhotic patients and hepatic carcinoma patients control group was formed of 25 healthy subjects. They were all subjected to clinical examination, and laboratory investigations in the form of CBC and liver profile (serum billirubin, albumin, AST, ALT) and prothrombin time and concentration. All groups will be subjected to genotyping for polymorphism in IFN-Þ (+874T/A) and IL-10(-1082G/A) using AS-PCR method. Results: It was found that there is no association between IFN-Þ (+874T/A) and IL-10(-1082G/A) polymorphisms and different disease severities of hepatitis C . Conclusion: We concluded that these gene polymorphisms are not predictors of disease progression in patients with chronic hepatitis C
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Ma.I (Browse shelf(Opens below)) Not for loan 01010110069338000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Ma.I (Browse shelf(Opens below)) 69338.CD Not for loan 01020110069338000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

The aim of this work was to evaluate whether single nucleotide polymorphisms in interferon- gamma (IFN-Þ) (+874T/A) and interleukin-10 (IL-10) (-1082G/A) genes are associated with susceptibility and/or are markers of prognosis to chronic hepatitis C outcomes. Patients and methods: The study was performed on 100 participants; first group was formed of 25 non-cirrhotic patients with chronic hepatitis, and the second group (n=50) was formed of cirrhotic patients and hepatic carcinoma patients control group was formed of 25 healthy subjects. They were all subjected to clinical examination, and laboratory investigations in the form of CBC and liver profile (serum billirubin, albumin, AST, ALT) and prothrombin time and concentration. All groups will be subjected to genotyping for polymorphism in IFN-Þ (+874T/A) and IL-10(-1082G/A) using AS-PCR method. Results: It was found that there is no association between IFN-Þ (+874T/A) and IL-10(-1082G/A) polymorphisms and different disease severities of hepatitis C . Conclusion: We concluded that these gene polymorphisms are not predictors of disease progression in patients with chronic hepatitis C

Issued also as CD

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