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Bioavailability enhancement for a central nervous system acting drug / Rania Moataz Ibrahim Eldahmy ; Supervised Nabaweya Abdelaziz , Omaima Elgazayerly , Ibrahim Elsayed Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rania Moataz Ibrahim Eldahmy , 2016Description: 226 P. : charts , facsimiles ; 25cmOther title:
  • تعزيز الاتاحة الحيوية لعقار مؤثر على الجهاز العصبى المركزى [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Vinpocetine is a CNS acting drug, it is used for treatment of many diseases like depression, Alzheimer and many cerebrovascular diseases. Vinpocetine has limited oral use due to its low water solubility, slow dissolution rate, poor absorption and significant first-pass metabolism that led to very low bioavailability. Additionally, it has very rapid elimination rate with short half- life that results in frequent drug dosing (three times daily), that increases side effects, toxicity and decreases patient compliance. The objective of this study was to enhance the bioavailability of Vinpocetine by developing new nanostructured formulae Finally, the nanostructured gels of oleic acid could be considered as promising nanocarriers for transmucosal and transdermal drug delivery of Vinpocetine
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2016.Ra.B (Browse shelf(Opens below)) Not for loan 01010110069343000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2016.Ra.B (Browse shelf(Opens below)) 69343.CD Not for loan 01020110069343000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Vinpocetine is a CNS acting drug, it is used for treatment of many diseases like depression, Alzheimer and many cerebrovascular diseases. Vinpocetine has limited oral use due to its low water solubility, slow dissolution rate, poor absorption and significant first-pass metabolism that led to very low bioavailability. Additionally, it has very rapid elimination rate with short half- life that results in frequent drug dosing (three times daily), that increases side effects, toxicity and decreases patient compliance. The objective of this study was to enhance the bioavailability of Vinpocetine by developing new nanostructured formulae Finally, the nanostructured gels of oleic acid could be considered as promising nanocarriers for transmucosal and transdermal drug delivery of Vinpocetine

Issued also as CD

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