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Progesterone versus placebo as a neuroprotective agent in patients with severe TBI / Khaled Mohammed Taher Ahmed ; Supervised Ahmed Abdelaziz Hegazy , Safinaz Hassan Osman , Ahmed Salah Eldin Kamel

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Khaled Mohammed Taher Ahmed , 2015Description: 56 P. ; 25cmOther title:
  • دراسة لاستخدام البروجستيرون كمادة تحمى الجهاز العصبى فى مرضى ما بعد اصابات المخ الشديدة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neurosurgery Summary: BACKGROUND: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials involving patients with TBI. METHODS: We conducted a single-blinded, randomized, controlled clinical trial, in which patients with severe acute TBI (Glasgow Coma Scale of 4 to 9, with lower scores indicating a lower level of consciousness) were randomly assigned to receive intramuscular progesterone or placebo. Treatment was initiated within 12hours after injury and administrated for 5 consecutive days. The primary end points were the Glasgow Outcome Scale score at 14 days after injury, and measurement of serum TNF- alpha. RESULTS: Our results indicate no statistically significant difference in Glasgow outcome scale (GOS), or in the decrease of TNF alpha level between study and placebo groups (P > 0.05). CONCLUSIONS: This clinical trial did not show a benefit of progesterone over placebo in the improvement of outcomes in patients with acute TBI
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.20.M.Sc.2015.Kh.P (Browse shelf(Opens below)) Not for loan 01010110069385000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.20.M.Sc.2015.Kh.P (Browse shelf(Opens below)) 69385.CD Not for loan 01020110069385000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neurosurgery

BACKGROUND: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials involving patients with TBI. METHODS: We conducted a single-blinded, randomized, controlled clinical trial, in which patients with severe acute TBI (Glasgow Coma Scale of 4 to 9, with lower scores indicating a lower level of consciousness) were randomly assigned to receive intramuscular progesterone or placebo. Treatment was initiated within 12hours after injury and administrated for 5 consecutive days. The primary end points were the Glasgow Outcome Scale score at 14 days after injury, and measurement of serum TNF- alpha. RESULTS: Our results indicate no statistically significant difference in Glasgow outcome scale (GOS), or in the decrease of TNF alpha level between study and placebo groups (P > 0.05). CONCLUSIONS: This clinical trial did not show a benefit of progesterone over placebo in the improvement of outcomes in patients with acute TBI

Issued also as CD

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