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Effect of trigonelline on the metabolic and biochemical changes associated with insulin resistance in rats / Ahmed Abdelfatah Abdallah Sedik ; Supervised Amer Ramadan Ali Ayad , Nehal Aly Afifi , Emad Yousef Erian

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Abdelfatah Abdallah Sedik , 2016Description: 127 P. : charts , facsimiles ; 25cmOther title:
  • تأثير تريجونيلين على التغيرات ا{uئإئ٧}يضية و البيوكيميائية المصاحبة لمقاومة ا{uئإئ٧}نسولين بالجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology Summary: The present study was designed to evaluate the effect of trigonelline (TRIG) on the metabolic and biochemical changes associated with high fat high fructose induced- insulin resistance in rats. Rats were rendered insulin resistant by adding high-fat diet (60 kcal/100 kcal saturated fat) and 10% fructose in the drinking water] for 8 weeks,. The effects of TRIG in doses (50 and100 mg/kg) were evaluated compared with sitagliptin (SITA), the standard anti-diabetic drug, in a dose (5 mg/kg). Moreover, the study was extended to evaluate the effect of the combination between TRIG and SITA in a dose (50 mg/kg) + (5mg/kg). The obtained results showed that TRIG has a beneficial effect on the hepatic complications associated with insulin resistance in rats due to improving the insulin signaling pathway and its antihyperlipidemic effect. The study concluded that concomitant treatment with TRIG and SITA has a promising effect on the metabolic and biochemical changes and molecular alterations associated with insulin resistance
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.M.Sc.2016.Ah.E (Browse shelf(Opens below)) Not for loan 01010110069474000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.M.Sc.2016.Ah.E (Browse shelf(Opens below)) 69474.CD Not for loan 01020110069474000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

The present study was designed to evaluate the effect of trigonelline (TRIG) on the metabolic and biochemical changes associated with high fat high fructose induced- insulin resistance in rats. Rats were rendered insulin resistant by adding high-fat diet (60 kcal/100 kcal saturated fat) and 10% fructose in the drinking water] for 8 weeks,. The effects of TRIG in doses (50 and100 mg/kg) were evaluated compared with sitagliptin (SITA), the standard anti-diabetic drug, in a dose (5 mg/kg). Moreover, the study was extended to evaluate the effect of the combination between TRIG and SITA in a dose (50 mg/kg) + (5mg/kg). The obtained results showed that TRIG has a beneficial effect on the hepatic complications associated with insulin resistance in rats due to improving the insulin signaling pathway and its antihyperlipidemic effect. The study concluded that concomitant treatment with TRIG and SITA has a promising effect on the metabolic and biochemical changes and molecular alterations associated with insulin resistance

Issued also as CD

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