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New approaches for the synthesis of derivatives of some extracted naturally occurring materials together with their cytotoxic evaluation / Amira Saad Teleb Azab ; Supervised Hamdi M. Hassaneen , Raafat M. Mohareb

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Amira Saad Teleb Azab , 2015Description: 189 P. : charts , facsimiles , photographs ; 25cmOther title:
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: The present work is intended to shade more light on investigating good candidates of anti-skin cancer drugs. Four medicinal plants were collected, and identified; they are: Aloe barbadensis Miller, Eugenia caryophyllata Thumb, Piper nigrum Linn, and Thymus vulgaris L. In this study, the naturally occurring compounds, namely; Aloins, Eugenol, Piperine, and Thymol respectively were extracted from Aloe vera, Eugenia caryophyllata Thumb, Piper nigrum, and Thymus vulgaris L. by using Steam distillation method. The extracted compounds were then implemented in a number of different heterocyclization reactions. Structure elucidation and characterization of these pure compounds were carried out using different spectral analyses. The cytotoxicity of each obtained compound was tested against tumor and normal cell lines in order to investigate good candidates of anti-cancer drugs
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2015.Am.N (Browse shelf(Opens below)) Not for loan 01010110069488000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2015.Am.N (Browse shelf(Opens below)) 69488.CD Not for loan 01020110069488000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The present work is intended to shade more light on investigating good candidates of anti-skin cancer drugs. Four medicinal plants were collected, and identified; they are: Aloe barbadensis Miller, Eugenia caryophyllata Thumb, Piper nigrum Linn, and Thymus vulgaris L. In this study, the naturally occurring compounds, namely; Aloins, Eugenol, Piperine, and Thymol respectively were extracted from Aloe vera, Eugenia caryophyllata Thumb, Piper nigrum, and Thymus vulgaris L. by using Steam distillation method. The extracted compounds were then implemented in a number of different heterocyclization reactions. Structure elucidation and characterization of these pure compounds were carried out using different spectral analyses. The cytotoxicity of each obtained compound was tested against tumor and normal cell lines in order to investigate good candidates of anti-cancer drugs

Issued also as CD

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