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Influence of cardiac diseases on plasma brain natriuretic peptide level in chronic hemodialysis and kidney transplant patients / Rasha Ahmed Darwish ; Supervised Mohamed Hany Hafez , Alaa Abdelhameed , Eman Farouk Ramzy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rasha Ahmed Darwish , 2015Description: 206 P. : charts , facsimiles ; 25cmOther title:
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: OBJECTIVE : To evaluate how the cardiac Biomarker N-terminal pro-brain natriuretic peptide may be utilized in predicting cardiovascular disease and outcome stratification in CKD and renal transplantation patients. Also, to define the best cut off reference value of NT pro-BNP in this category of patients in specific cardiac pathologies. METHODS: Case control study including 10 non-cardiac hemodialysis patients, 20 maintenance hemodialysis patients known to have cardiac diseases and in 15 renal transplantation patients who were on hemodialysis. We measured the level of NT-Pro BNP and Echocardiogram was performed in all of them. Inferior vena cava diameter (IVCD) measurement by ultrasonography was done being a non-invasive tool for estimation of fluid status as it reflects intravascular volume changes. RESULTS : The raised levels of the Pro-BNP in the HDX cardiac was about 4 folds higher than the HDX non-cardiac controls, while it was 2 folds higher in the TX group compared to the control group. The NT-pro BNP in the three groups is elevated more than 10 fold the upper limit of normal. NT- pro BNP may be of help in the detection of the presence of cardiac diseases in hemodialysis when ranging from 4,000-4,500 ng/L. systolic dysfunction presence with an almost 70% specificity when its value was above 5,500 ng/L . In Transplantation, detection of cardiac cases if the cut-off value of 3,85 2.50 ng/L with 80% specificity. Also, the level of 4,500 ng/L could be used for doubting the presence of ventricular hypertrophy in TX. CONCLUSION : Renal transplantation reduces the risk of cardiovascular disease in comparison with dialyzed patients, but it still remains higher than in healthy people. NT-pro BNP cutoff limits can help in early detection of cardiac diseases in general in both Hemodialysis and transplantation patients
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2015.Ra.I (Browse shelf(Opens below)) Not for loan 01010110069544000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2015.Ra.I (Browse shelf(Opens below)) 69544.CD Not for loan 01020110069544000
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Cai01.11.18.Ph.D.2015.No.S Study of prediction of response to pegylated interferon plus ribavirin in hepatitis C patients by IL28B gene variation and its relation to other different predictors / Cai01.11.18.Ph.D.2015.No.S Study of prediction of response to pegylated interferon plus ribavirin in hepatitis C patients by IL28B gene variation and its relation to other different predictors / Cai01.11.18.Ph.D.2015.Ra.I Influence of cardiac diseases on plasma brain natriuretic peptide level in chronic hemodialysis and kidney transplant patients / Cai01.11.18.Ph.D.2015.Ra.I Influence of cardiac diseases on plasma brain natriuretic peptide level in chronic hemodialysis and kidney transplant patients / Cai01.11.18.Ph.D.2015.Ra.S Study of the role of anti phospholipase A2 receptor antibodies in monitoring of the clinical status in idiopathic membranous nephropathy in Egyptian patients / Cai01.11.18.Ph.D.2015.Ra.S Study of the role of anti phospholipase A2 receptor antibodies in monitoring of the clinical status in idiopathic membranous nephropathy in Egyptian patients / Cai01.11.18.Ph.D.2015.Sa.P The prevalence and clinical consequences of vitamin D deficiency and vitamin D receptor polymorphism in Egyptian patients suffering from systemic lupus erythematosus /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

OBJECTIVE : To evaluate how the cardiac Biomarker N-terminal pro-brain natriuretic peptide may be utilized in predicting cardiovascular disease and outcome stratification in CKD and renal transplantation patients. Also, to define the best cut off reference value of NT pro-BNP in this category of patients in specific cardiac pathologies. METHODS: Case control study including 10 non-cardiac hemodialysis patients, 20 maintenance hemodialysis patients known to have cardiac diseases and in 15 renal transplantation patients who were on hemodialysis. We measured the level of NT-Pro BNP and Echocardiogram was performed in all of them. Inferior vena cava diameter (IVCD) measurement by ultrasonography was done being a non-invasive tool for estimation of fluid status as it reflects intravascular volume changes. RESULTS : The raised levels of the Pro-BNP in the HDX cardiac was about 4 folds higher than the HDX non-cardiac controls, while it was 2 folds higher in the TX group compared to the control group. The NT-pro BNP in the three groups is elevated more than 10 fold the upper limit of normal. NT- pro BNP may be of help in the detection of the presence of cardiac diseases in hemodialysis when ranging from 4,000-4,500 ng/L. systolic dysfunction presence with an almost 70% specificity when its value was above 5,500 ng/L . In Transplantation, detection of cardiac cases if the cut-off value of 3,85 2.50 ng/L with 80% specificity. Also, the level of 4,500 ng/L could be used for doubting the presence of ventricular hypertrophy in TX. CONCLUSION : Renal transplantation reduces the risk of cardiovascular disease in comparison with dialyzed patients, but it still remains higher than in healthy people. NT-pro BNP cutoff limits can help in early detection of cardiac diseases in general in both Hemodialysis and transplantation patients

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