Association between serum IGF-1, HOMA-IR, estimated glomerular filtration rate in obese patients with different stages of hepatic steatosis / Heba Mahmoud Mohamed Ibrahim ; Supervised Mohamed Sherif Mogawer , Mona Abdelmonem Hegazy , Laila Ahmed Rashed

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Heba Mahmoud Mohamed Ibrahim

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TextLanguage: English Publication details: Cairo : Heba Mahmoud Mohamed Ibrahim , 2015Description: 188 P. : charts , facsimiles ; 25cmOther title:

العلاقة بين نسبة معامل النمو الشبيه بالأنسولين 1و معادلة مؤشر تقييم نموذج التوازن لمقاومة الأنسولين ومعدل الترشيح الكلوي في مرضى السمنة الذين يعانون من مرض الكبد الدهني بدرجات مختلفة [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury in many countries around the world. The histological changes range over a wide spectrum, extending from simple steatosis, which is generally progressive, to non alcoholic steatohepatitis (NASH) which may progress to liver fibrosis, liver cirrhosis, liver cell failure, and sometimes even hepatocellular carcinoma. Liver biopsy is recommended as a gold standard method for the diagnosis and staging of steatosis and fibrosis in patients with NAFLD. low IGF-I level are a consequence of the presence of both NASH/advanced fibrosis in adult patients proved by liver biopsy which is a features of abdominal obesity and insulin resistance (HOMA-IR) and all contribute to the reduced eGFR. Objectives: Assessing the link between HOMA-IR, IGF-I level and eGFR in obese patient with different grades of severity of hepatic steatosis proved by liver biopsy. Results: There were a significant difference between NAFLD patients and normal control participants regarding anthropometric measurements, liver enzymes (ALT, AST and GGT), fasting blood sugar and total lipid profile. HOMA-IR was higher in NAFLD patients compared to control participant and reached higher level in NASH patients compared to simple steatosis patients. IGF-I; was highly significantly lower in NAFLD patients compared to control participants and was higher in non-NASH compared to NASH patients. eGFR was significantly lower in NAFLD patients compared to control participant, to reach below 60ml/min in NASH subgroup resulting in p value of 0.004 when compared to patients with border line NASH and non-NASH. Conclusion: There was a definitive association betweenlow IGF-1 ,high level of HOMA-IR ,and reduced eGFR with the incidence of NAFLD with different grades of severity. In NAFLD patients eGFR was lower than 90ml/min, and lower than 60ml/min in NASH and border line NASH patients

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.18.M.Sc.2015.He.A (Browse shelf(Opens below))		Not for loan		01010110069678000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.18.M.Sc.2015.He.A (Browse shelf(Opens below))	69678.CD	Not for loan		01020110069678000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury in many countries around the world. The histological changes range over a wide spectrum, extending from simple steatosis, which is generally progressive, to non alcoholic steatohepatitis (NASH) which may progress to liver fibrosis, liver cirrhosis, liver cell failure, and sometimes even hepatocellular carcinoma. Liver biopsy is recommended as a gold standard method for the diagnosis and staging of steatosis and fibrosis in patients with NAFLD. low IGF-I level are a consequence of the presence of both NASH/advanced fibrosis in adult patients proved by liver biopsy which is a features of abdominal obesity and insulin resistance (HOMA-IR) and all contribute to the reduced eGFR. Objectives: Assessing the link between HOMA-IR, IGF-I level and eGFR in obese patient with different grades of severity of hepatic steatosis proved by liver biopsy. Results: There were a significant difference between NAFLD patients and normal control participants regarding anthropometric measurements, liver enzymes (ALT, AST and GGT), fasting blood sugar and total lipid profile. HOMA-IR was higher in NAFLD patients compared to control participant and reached higher level in NASH patients compared to simple steatosis patients. IGF-I; was highly significantly lower in NAFLD patients compared to control participants and was higher in non-NASH compared to NASH patients. eGFR was significantly lower in NAFLD patients compared to control participant, to reach below 60ml/min in NASH subgroup resulting in p value of 0.004 when compared to patients with border line NASH and non-NASH. Conclusion: There was a definitive association betweenlow IGF-1 ,high level of HOMA-IR ,and reduced eGFR with the incidence of NAFLD with different grades of severity. In NAFLD patients eGFR was lower than 90ml/min, and lower than 60ml/min in NASH and border line NASH patients

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