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Micafungin as a prophylactic antifungal during induction phase of chemotherapy for pediatric acute lymphoblastic leukemia / Afaf Mohammad Mahmoud ; Supervised Lobna Mohamed Shalaby , Hadir Ahmad Elmahallawy , Sahar Ahmad Khalil

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Afaf Mohammad Mahmoud , 2016Description: 89 P. ; 25cmOther title:
  • للوقاية من الاصابة بالفطريات خلال الفترة التحفيزية من علاج سرطان الدم الليمفاوى الحاد فى الاطفال Micafungin استخدام عقار المايكافنجين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology Summary: Background: Invasive fungal infection (IFI) remains a major cause of infectious morbidity and mortality in neutropenic patients receiving chemotherapy or hematopoietic stem cell transplantation (HSCT). Micafungin exhibits broad antifungal activity against both Aspergillus and Candida species. Objective: We performed a prospective study to determine the efficacy, safety, and tolerability of prophylactic micafungin against IFI in pediatric neutropenic patients during induction chemotherapy for acute lymphoblastic leukemia (ALL). Results: Treatment success rate, defined as absence of proven, probable, or possible IFIs, was 75%. No adverse events were observed that could be related to micafungin prophylaxis. Conclusions: These results suggest that prophylactic micafungin is well tolerated and may prevent IFIs in pediatric patients with neutropenia receiving chemotherapy
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.05.M.Sc.2016.Af.M (Browse shelf(Opens below)) Not for loan 01010110069713000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.05.M.Sc.2016.Af.M (Browse shelf(Opens below)) 69713.CD Not for loan 01020110069713000

Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology

Background: Invasive fungal infection (IFI) remains a major cause of infectious morbidity and mortality in neutropenic patients receiving chemotherapy or hematopoietic stem cell transplantation (HSCT). Micafungin exhibits broad antifungal activity against both Aspergillus and Candida species. Objective: We performed a prospective study to determine the efficacy, safety, and tolerability of prophylactic micafungin against IFI in pediatric neutropenic patients during induction chemotherapy for acute lymphoblastic leukemia (ALL). Results: Treatment success rate, defined as absence of proven, probable, or possible IFIs, was 75%. No adverse events were observed that could be related to micafungin prophylaxis. Conclusions: These results suggest that prophylactic micafungin is well tolerated and may prevent IFIs in pediatric patients with neutropenia receiving chemotherapy

Issued also as CD

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