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Novel biomarkers of acute kidney injury following living donor liver transplantation / Ahmed Mohamed Abdelghany ; Supervised Mohamed Sherif Mogawer , Mostafa Abdelrahman Elshazly , Samah Mohamed Abdelhamid

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Mohamed Abdelghany , 2016Description: 123 P. : charts , facsimiles ; 25cmOther title:
  • دلالات حيوية جديدة للكشف المبكر عن القصور الكلوي الناتج عن جراحة زراعة الكبد للمتبرعين الاحياء [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Acute kidney injury after liver transplantation is a common complication. Renal ischemia reperfusion (IR) injury is a frequent cause of clinical AKI. Unfortunately, creatinine increase is a delayed and unreliable indicator of AKI and its level is affected by several factors other than the GFR. For this reason, acute Dialysis Quality Initiative (ADQI), the AKI network (AKIN) and the American society of nephrology developed the validity of novel biomarkers of AKI. Objectives: The aim of this work is to detect acute kidney injury in perioperative period following Living donor liver transplantation using (Renalase & NGAL) as novel biomarkers, and to assess their clinical utility for detection of acute renal injury related to Calcineurin Inhibitors with possible adjustment of new therapeutic strategies. Results: Although there was significant increase in creatinine values and significant decline in serum renalase values postoperative, serum renalase and Neutrophil gelatinase-associated lipocalin (NGAL) did not show significant difference between acute kidney injury (AKI) and non-AKI groups
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2016.Ah.N (Browse shelf(Opens below)) Not for loan 01010110069827000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2016.Ah.N (Browse shelf(Opens below)) 69827.CD Not for loan 01020110069827000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Acute kidney injury after liver transplantation is a common complication. Renal ischemia reperfusion (IR) injury is a frequent cause of clinical AKI. Unfortunately, creatinine increase is a delayed and unreliable indicator of AKI and its level is affected by several factors other than the GFR. For this reason, acute Dialysis Quality Initiative (ADQI), the AKI network (AKIN) and the American society of nephrology developed the validity of novel biomarkers of AKI. Objectives: The aim of this work is to detect acute kidney injury in perioperative period following Living donor liver transplantation using (Renalase & NGAL) as novel biomarkers, and to assess their clinical utility for detection of acute renal injury related to Calcineurin Inhibitors with possible adjustment of new therapeutic strategies. Results: Although there was significant increase in creatinine values and significant decline in serum renalase values postoperative, serum renalase and Neutrophil gelatinase-associated lipocalin (NGAL) did not show significant difference between acute kidney injury (AKI) and non-AKI groups

Issued also as CD

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