Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: It was suggested that vitamin D has both direct and indirect effects on modifying the lipid profile and that the effect of vitamin D on decreasing serum levels of triglycerides (TG) may occur through regulatory action that increases the activity of lipoprotein lipase in adiposity. Aim of the work: To investigate the relationship between serum levels of 25(OH) D and lipid profiles in patients with T1D and to investigate the differences between lipid profiles (LDL, HDL, Cholesterol, TG) before and after supplementation with vitamin D (for 4 months) in patients with vitamin D deficiency. Results: The mean age of the studied patients was 12.56 ±3.53 years, 25(OH) D3 levels ranged from 0.1 to 62 ng/ml with a mean of 25.95 ng/ml. There was no significant correlation between vitamin D level and different studied parameters (age, diabetes duration, hypoglycemia frequency, DKA frequency, insulin dose, HbA1c, thyroid functions and lipid profile) within the study group (p>0.05). When patients with vitamin D deficiency were compared to those with normal levels, no significant difference was found except in family history of coronary heart disease (p=0.036) and free T4 (p=0.035). After 4 mo of vitamin D supplementation for those with vitamin D deficiency, the mean difference (at 0 & 4 mo) in HbA1c and LDL between the 2 groups was statistically significant (p=0.04 & 0.02 respectively). Conclusion: Vitamin D deficiency is highly prevalent in patients with T1D.There was no significant correlation between 25OHD levels and lipid profile. Vitamin D deficient patients with T1D and dyslipidemia showed improvement in HbA1c and LDL mean difference after 4 mo of vitamin D supplementation

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