Comparison of misoprostol VS Dinoprostone in Induction of labour / Mohammed Ibrahim Ibrahim Mekhimer ; Supervised Mohammed Hassan Mostafa , Ahmed Mohammed Magdy , Hossam Eldin Osama Elshenoufy

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Obstetrics and Gynecology

Induction of labor is an integral part of obstetric practice. In modern obstetrics, it is mainly attempted when continuation of pregnancy may harm either mother ,foetus or both. Inductionof labor has been traditionally done by oxytocin infusion but numerous studies have shown that it is unable to achieve equally gratifying results in un-favourablecervix . Prostaglandins are frequently used for labor induction in pregnant women with unfavourable cervix. Various PG preparations including misoprostol vaginal tablets, dinoprostone vaginal tablets, gel and vaginal insert are commercially available to be used in labor induction. The aim of this study :To compare effectiveness of Dinoprostone vaginal inserts versus Misoprostol vaginal inserts in induction of labor as regard mode of delivery ,number of doses and induction active labour interval ,and the safety of the mother as regard uterine hyperstimulation and rupture uterus and the fetus as regard fetal distress and the outcome. Patients and Methods :In our study 100 women {u2265}37 weeks pregnancy with Bishop score {u2264} 6 were randomized into two groups: Misoprostol group ( group A=50 women) Dinoprostone group (group B=50) . Both preparations were given vaginally every 6 hours for a maximum of 4 doses in misoprostol group and 2 doses in the dinoprostone group. Active labor phase is defined as cervical dilatation of 4 cm or more

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