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Synthesis of some new pyrazolo[1,5-a]pyrimidine derivatives / Kamal Abdullateef Alamour ; Supervised Nadia Hanafy Metwally

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Kamal Abdullateef Alamour , 2016Description: 132 , 5 P. : facsimiles ; 25cmOther title:
  • [1,5a]تشييد بعض مشتقات البيرازولو بيريميدين الجديدة [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: The original work of this thesis includes: The condensation of 2-cyanomethylpyrazolo[1,5-a]pyrimidines 3a,b with various aromatic aldehydes afforded the corresponding arylidene of substituted pyrazolo[1,5- a]pyrimidines 5a-p. The reaction of 3a,b with phenyl isothiocyanate, followed by addition of Ü-haloesters, Ü-haloketones and bromoacetonitrile afforded the polyheterocyclic compounds based-pyrazolo[1,5-a]pyrimidine derivatives. Also, the enamines of compounds 3a,b react with each of hydrazine hydrate, guanidine hydrochloride and hydroxylamine hydrochlorideto give the 5- aminopyrazolo[4'',3'':5',6']pyrido[4',3':3,4]pyrazolo[1,5-a]pyrimidine 23a,b, pyrimidino[4,5-b]pyrimidino[1',2-5,1]pyrazolo[3,4-d] pyrimidine 26a,b and isoxazolo[4'',5'':5',6']pyrido[4',3':3,4]pyrazolo[1,5-a]pyrimidine 29a,b, respectively. The structures of all the newly synthesized products were established by their elemental, spectral data and plausible mechanism has been postulated to account for their formation
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2016.Ka.S (Browse shelf(Opens below)) Not for loan 01010110070026000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2016.Ka.S (Browse shelf(Opens below)) 70026.CD Not for loan 01020110070026000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The original work of this thesis includes: The condensation of 2-cyanomethylpyrazolo[1,5-a]pyrimidines 3a,b with various aromatic aldehydes afforded the corresponding arylidene of substituted pyrazolo[1,5- a]pyrimidines 5a-p. The reaction of 3a,b with phenyl isothiocyanate, followed by addition of Ü-haloesters, Ü-haloketones and bromoacetonitrile afforded the polyheterocyclic compounds based-pyrazolo[1,5-a]pyrimidine derivatives. Also, the enamines of compounds 3a,b react with each of hydrazine hydrate, guanidine hydrochloride and hydroxylamine hydrochlorideto give the 5- aminopyrazolo[4'',3'':5',6']pyrido[4',3':3,4]pyrazolo[1,5-a]pyrimidine 23a,b, pyrimidino[4,5-b]pyrimidino[1',2-5,1]pyrazolo[3,4-d] pyrimidine 26a,b and isoxazolo[4'',5'':5',6']pyrido[4',3':3,4]pyrazolo[1,5-a]pyrimidine 29a,b, respectively. The structures of all the newly synthesized products were established by their elemental, spectral data and plausible mechanism has been postulated to account for their formation

Issued also as CD

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