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Pharmacokinetics/pharmacodynamics of cefquinome in healthy goats and goats with staphylococcus aureus-induced mastitis / Shymaa Ahmed Elbadawy Elsherbiny Ali Alashry ; Supervised Aziza Mahrous Mohamed Amer , Gehan Mohamed Kamel , Kamal Mamon Eldeib

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shymaa Ahmed Elbadawy Elsherbiny Ali Alashry , 2016Description: 272 P. : charts , facsimiles ; 25cmOther title:
  • المسار الحركى و الديناميكى لسيفكونيم فى الماعز السليمة و المصابة بالتهاب الضرع المحدث بميكروب استافيلكوكس اوريوس [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology Summary: Values for pharmacokinetic variables are usually obtained in healthy animals, whereas drugs are frequently administered to diseased animals. This study investigated cefquinome pharmacokinetics in healthy goats and goats with experimentally induced mastitis. Five adult lactating goats received each of the following two treatments of 75mg of cefquinome intramammary infusion and intravenous injection before and after induction of clinical mastitis. Cefquinome concentrations were determined in plasma and skimmed milk samples using microbiological assay and high performance liquid chromatography. Pharmacodynamics was investigated using the California Mastitis Test, electrical conductivity, the sodium and potassium concentrations and pH of milk. Both MA and HPLC analytical methodologies yielded statistically similar mean values for the cefquinome concentration-time relationship in skimmed milk and plasma and similar values for almost all calculated pharmacokinetic indices; however, HPLC had a lower limit of quantification LOQ and coefficient of variation, and a higher correlation coefficient for standard curves. Experimentally induced mastitis decreased the maximal cefquinome concentration and shortened the elimination half-time in milk when compared to healthy goats. In conclusion, MA provides a simple, practical and inexpensive method for measuring cefquinome concentrations in skimmed milk and plasma samples from goats, while, HPLC proved to be more sensitive, specific and accurate. Mastitis facilitated the absorption of cefquinome from the mammary gland of lactating goats and induced marked changes in milk pH, sodium and potassium concentrations, which emphasizes the importance of performing pharmacokinetic studies in infected animals
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.Ph.D.2016.Sh.P (Browse shelf(Opens below)) Not for loan 01010110070030000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.Ph.D.2016.Sh.P (Browse shelf(Opens below)) 70030.CD Not for loan 01020110070030000

Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

Values for pharmacokinetic variables are usually obtained in healthy animals, whereas drugs are frequently administered to diseased animals. This study investigated cefquinome pharmacokinetics in healthy goats and goats with experimentally induced mastitis. Five adult lactating goats received each of the following two treatments of 75mg of cefquinome intramammary infusion and intravenous injection before and after induction of clinical mastitis. Cefquinome concentrations were determined in plasma and skimmed milk samples using microbiological assay and high performance liquid chromatography. Pharmacodynamics was investigated using the California Mastitis Test, electrical conductivity, the sodium and potassium concentrations and pH of milk. Both MA and HPLC analytical methodologies yielded statistically similar mean values for the cefquinome concentration-time relationship in skimmed milk and plasma and similar values for almost all calculated pharmacokinetic indices; however, HPLC had a lower limit of quantification LOQ and coefficient of variation, and a higher correlation coefficient for standard curves. Experimentally induced mastitis decreased the maximal cefquinome concentration and shortened the elimination half-time in milk when compared to healthy goats. In conclusion, MA provides a simple, practical and inexpensive method for measuring cefquinome concentrations in skimmed milk and plasma samples from goats, while, HPLC proved to be more sensitive, specific and accurate. Mastitis facilitated the absorption of cefquinome from the mammary gland of lactating goats and induced marked changes in milk pH, sodium and potassium concentrations, which emphasizes the importance of performing pharmacokinetic studies in infected animals

Issued also as CD

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