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Role of PNPLA3 gene polymorphism in progression to NASH in Egyptian patients with NAFLD / Ahmed Ramadan Mohamed Ali ; Supervised Eman Medhat Hassan , Hanan Hassan Fouad , Hany Mahmoud Khattab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Ramadan Mohamed Ali , 2016Description: 156 P. : charts , facsimiles ; 25cmOther title:
  • دور تعدد الأنواع الجينية للبتاتين فوسفوليباز{u٠٦ئ٣} في التطور الى الالتهاب الكبدى الدهنى اللاكحولى فى المرضى المصريين المصابين بالكبد الدهنى اللاكحولي [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury. It extends from simple steatosis, which is generally progressive, to NASH which may progress to liver fibrosis, liver cirrhosis, liver cell failure, and sometimes even hepatocellular carcinoma(HCC). Patatin like phosphlipase (PNPLA3) plays a key role in a pathogenesis of NAFLD and progression from simple steatosis to NASH with fibrosis. Objectives: Study the effect of Single nucleotide polymorphisms (SNPs) in PNPLA3 genes on susceptibility to NAFLD and disease progression. Results: There is a definitive association between heterozygous and the non- wild homozygous polymorphisms of Rs738409 PNPLA3 and NAFLD. In NAFLD patients subgroups; the GG genotype of PNPLA3 gene was higher in NAFLD patient's subgroup than controls GG occurs in 13 patients (43.3%) and in 2 controls (10%) with P value 0.002. There were a significant difference between NAFLD patients and normal control participants regarding anthropometric measurements, liver enzymes (ALT, AST). Conclusion: There was an association between polymorphisms of the studied SNPs of Rs738409 PNPLA3 gene with the incidence of NAFLD and the severity of the disease.
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2016.Ah.R (Browse shelf(Opens below)) Not for loan 01010110070148000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2016.Ah.R (Browse shelf(Opens below)) 70148.CD Not for loan 01020110070148000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury. It extends from simple steatosis, which is generally progressive, to NASH which may progress to liver fibrosis, liver cirrhosis, liver cell failure, and sometimes even hepatocellular carcinoma(HCC). Patatin like phosphlipase (PNPLA3) plays a key role in a pathogenesis of NAFLD and progression from simple steatosis to NASH with fibrosis. Objectives: Study the effect of Single nucleotide polymorphisms (SNPs) in PNPLA3 genes on susceptibility to NAFLD and disease progression. Results: There is a definitive association between heterozygous and the non- wild homozygous polymorphisms of Rs738409 PNPLA3 and NAFLD. In NAFLD patients subgroups; the GG genotype of PNPLA3 gene was higher in NAFLD patient's subgroup than controls GG occurs in 13 patients (43.3%) and in 2 controls (10%) with P value 0.002. There were a significant difference between NAFLD patients and normal control participants regarding anthropometric measurements, liver enzymes (ALT, AST). Conclusion: There was an association between polymorphisms of the studied SNPs of Rs738409 PNPLA3 gene with the incidence of NAFLD and the severity of the disease.

Issued also as CD

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