Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Oncology (chinical)

Aim: Clinico-epidemiological study for laryngeal cancer patients, treated by radical radiotherapy (RT) ± chemotherapy (CT). Prognostic factors, treatment modalities, and their effect on loco-regional (LRC) and overall survival (OS) were studied. Results: mean age was 60 years. Squamous cell carcinoma was the most common pathological type (93%). Glottic carcinoma represent 57.4% while supraglottic carcinoma represent 38.3%. T1 represents 58.6% of early stage, while T3 represents 56.4% of advanced stage. Node negative disease represented 71.6%, while node +ve represented 28.4% of patients. 61% of patients were treated by radical RT, while 39% received chemoradiotherapy. Forty seven patients with advanced stage (33.3%) received CCRT while 35.2% received induction CT. Out of 141 patients, 116 patients completed the RT course (82.2%). The majority of patients (63.8%) achieved complete remission (CR). Locoregional failure was affecting 14 patients, and salvage surgery was done for 13 patients. The 5-year LRC and OS rates for all studied patients were 53.4% and 60% respectively, compared to 65.1% and 71.5% for early stage laryngeal cancer and 47.3% and 46.3% for advanced stage respectively. The 2, 3, and 5 year laryngectomy free survival (LFS) for advanced stage was 41.7%, 34%, and 31% respectively. Adverse prognostic factors affecting OS included; pathological grade, prolongation of overall RT treatment time and RT course discontinuation, while adverse prognostic factors affecting LRC were the pathological grade and disease subsite.

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