Periostin as a systemic biomarker of eosinophilic airway inflammation in asthmatic children / Radwa Ezzat Amin Mohamed ; Supervised Hala Hamdy Shaaban , Hanan Mohsen Osman , Salma Mohamed Said

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Th2_eosinophilic inflammation has been considered to be the dominant inflammatory pattern in asthma. Eosinophilic disease is a strong predictor of corticosteroid responsiveness. Direct airway sampling is technically challenging and impractical.Serum periostin may be a biomarker of eosinophilic asthma and it may help in asthma stratification prior to therapeutic interventions.The aim of this study is to explore serum Periostin as potential systemic biomarker in eosinophilic asthma in children and to correlate it with type of asthma. Subjects and methods: This is a cross sectional study, 60 asthmatic children with varying degree of severity, aged from 1-12 years were recruited from allergy and pulmonology clinic at Abo El Rish children's hospital, Cairo University and studied in comparison to 20 healthy age and sex matched children. Serum periostin level and complete blood picture including absolute eosinophilic count are measured in both asthmatics and controls. Results: Serum periostin levelis higher in asthmatic children compared to controls with with p-value <0.001, Serumperiostinlevel was significantly higher in severe asthmatics inspite maximum ICS compared to mild- moderate asthmatics with p-value<0.0001.There is positive correlation between serum periostin level and degree of severity of asthma with p- value<0.0001. Serum periostin level has highest value in allergic rhinitis compared to allergic conjunctivitis and eczema, no significant correlation was found between periostin level and patients with positive family history of atopy p-value=0.187. Conclusion: These findings imply that serum periostin level may be involved in the pathogenesis of eosinophilic asthma. Serum level of periostin as a biomarker has the potential to be used as noninvasive inflammatory markers for evaluation of airway inflammation in asthma

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