Design, synthesis, and biological evaluation of novel coumarin derivatives as potential antitumor agents / Rana Mohamed Mohamed Mohamed ; Supervised Kamilia M. Amin , Mohamed M. Hussein , Sahar M. Abou Seri

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Anticancer drugs have traditionally been targeted to destroy the rapidly dividing cell by interrupting the cell division process. These drugs are effective cytotoxic agents. That{u2019}s why they exhibit severe side effects on normal proliferating tissues such as the hematopoietic system, gastrointestinal lining, and hair follicles. Combination therapy targeting different mechanisms sometimes offers better results with less toxic side effects. Currently, chemotherapy, radiotherapy, and surgery combined offer the best outcomes for cancer patients. Yet there are no 100% effective drugs to cure cancer. Furthermore, infections are a major cause of death in cancer; they not only occur frequently but also are often more severe than in other patients, less responsive to therapy and sometimes produced by organisms which are not pathogens in healthy people. Thus, there is a mutual relationship between cancer and infection that necessitate the discovery of new drugs targeting both diseases to increase the viability of patients and decreases the side effects. Coumarin derivatives have reported potent anticancer and antimicrobial activities with the multi target mechanism. Hence, they represent an attractive scaffold that can be used in designing new safe compounds with both anticancer and antimicrobial activities

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