Pharmacokinetic pharmacodynamic modeling of cefquinome in suckling calves normal and with respiratory signs / Mohammed Said Mohammed Saber Omar ; Supervised Aziza Mahrous Mohamed Amer , Monir Mohammed Abdelhalim , Kamal Mamon Eldeib

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

Pharmacokinetics and pharmacodynamics of cefquinome were studied in calves after intramuscular injection of cefquinome (2mg/kg B.WT) healthy and diseased calve alone and in combination with flunixin (1mg/ kg BW). Cefquinome was detected in plasma of calves from 5.0 minutes to 24 h. following IM injection. Cefquinome peak concentration C in max healthy calves was (0.783 ± 0.088 æg/ml), and with co-administration with flunixin 0.906 ± 0.102 and 0.916 ± 0.037æg/ml, respectively. The T in healthy calves (0.66 ± 0.09 h.) and 0.90 ± 0.10 h. in diseased max calves treated with cefquinome alone and 1.05 ± 0.20h diseased calves treated with cefquinome and flunixin. Pharmacokinetic/ Pharmacodynamic modeling after intramuscular administration of cefquinome in diseased calves treated with cefquinome (2 mg/kg B.WT) and with flunixin for 5 days, the clinical parameters showed rapid recovery in all treated groups. From the obtained data it could be concluded that cefquinome act effectively in treatment of bacterial respiratory disease in calves as well as the co-administartion of flunixin with cefquinome showed highly synergistic activity in treatment of bacterial respiratory disease (Pasterella infctions) in suckling cow calves

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