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Influence of CYP3A and ABCBI polymorphisms on tacrolimus dosing in kidney transplant patients / Dina Aly Ezzat Khafagy ; Supervised Omnia Ahmed Youssef , Walaa Ahmed Rabie , Sahier Elkhashab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Dina Aly Ezzat Khafagy , 2016Description: 138 P. : charts , facsimiles ; 25cmOther title:
  • على جرعت عقار التاكروليمس فى مرضى زراعة الكلى ABCB1 و CYP3A5 تأثير االانماط الجينية لجينات [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Tacrolimus is an immunosuppressive drug characterized by a wide inter-individual variability in its pharmacokinetics. CYP3A5 and P-glycoprotein are important determinants of the tacrolimus metabolism. The aim of this study was to evaluate the influence of single nucleotide polymorphisms in the CYP3A5 gene and ABCB1 gene on tacrolimus trough concentration; moreover, it aimed to clarify the correlation between CYP3A5 enzyme concentration and the CYP3A5 polymorphisms in renal transplanted patients.Results : Tacrolimus trough was the highest among CYP3A5 homozygous mutant genotype (GG). Significant low serum CYP3A5 concentration level was found among homozygous mutant genotype (GG) of CYP3A5 SNP and high serum CYP3A5 concentration level was found among homozygous wild (AA) genotype. ROC curve showed that the serum level (1.95ng/ml) was indicative for presence of CYP3A5 homozygous wild genotypes (AA), no association was found between trough blood concentrations and ABCB1 genotypesز Conclusions: CYP3A5 wild genotype required a higher daily tacrolimus dose to maintain the target trough level compared with those with the CYP3A5 mutant genotype, CYP3A5 pharmacogenetic testing performed just before transplantation could contribute to a better individualization of immunosuppressive therapy.
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2016.Di.I (Browse shelf(Opens below)) Not for loan 01010110070432000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2016.Di.I (Browse shelf(Opens below)) 70432.CD Not for loan 01020110070432000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Tacrolimus is an immunosuppressive drug characterized by a wide inter-individual variability in its pharmacokinetics. CYP3A5 and P-glycoprotein are important determinants of the tacrolimus metabolism. The aim of this study was to evaluate the influence of single nucleotide polymorphisms in the CYP3A5 gene and ABCB1 gene on tacrolimus trough concentration; moreover, it aimed to clarify the correlation between CYP3A5 enzyme concentration and the CYP3A5 polymorphisms in renal transplanted patients.Results : Tacrolimus trough was the highest among CYP3A5 homozygous mutant genotype (GG). Significant low serum CYP3A5 concentration level was found among homozygous mutant genotype (GG) of CYP3A5 SNP and high serum CYP3A5 concentration level was found among homozygous wild (AA) genotype. ROC curve showed that the serum level (1.95ng/ml) was indicative for presence of CYP3A5 homozygous wild genotypes (AA), no association was found between trough blood concentrations and ABCB1 genotypesز Conclusions: CYP3A5 wild genotype required a higher daily tacrolimus dose to maintain the target trough level compared with those with the CYP3A5 mutant genotype, CYP3A5 pharmacogenetic testing performed just before transplantation could contribute to a better individualization of immunosuppressive therapy.

Issued also as CD

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