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Association of TAP2 gene polymorphisms (TAP2-565, TAP2- 665) with B-CLL / Hebatalla Sayed Farid Hassan ; Supervised Doha Abdelhamid Mokhtar , Asmaa Ahmed Abdelal , Mosaad Mahmoud Elgammal

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hebatalla Sayed Farid Hassan , 2016Description: 191 P. : charts , facsimiles ; 25cmOther title:
  • التحورات الجينية لجين تاب ٢ وعلاقتها بمرض سرطان الدم الليمفاوى المزمن ذو نوعية الخلايا (بي [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Transporter associated with antigen presenting (TAP) genes that localized in the major histocompatability complex (MHC) class II region are playing a key role in endogenous pathways for antigen presentation. Polymorphisms of these genes have been reported to be common in different types of cancer. In the present study, TAP2-565 and TAP2-665 polymorphisms were determined using a PCR-RFLP method in 50 patients with chronic lymphocytic leukemia (CLL) as well as 65 age and sex matched adults were enrolled as a control group. TAP2-565 GA heterozygous genotype was found in 9/50 (18%) patients with B-CLL in comparison to 6/65 (9.2%) of control group (P value =0.135). The heterozygous type GA was only significantly associated with low red blood cell count and high lymphocytic count among CLL cases. TAP2-665 AG heterozygous genotype was found in 25/50 (50%) of patients with B- CLL in comparison to 29/65 (44.6%) of control group (P value =0.350). There was also a significant association between heterozygous type AG and some laboratory findings of CLL patients such as low hemoglobin level, low red blood cell count and high lymphocytic count. We found significant association between this genotype and worse prognosis in CLL cases according to both Binet staging system and Rai staging systems (P values = 0.014,0.021) respectively. Our results indicated that TAP2 gene polymorphisms (TAP2-565, TAP2-665) have no role as risk factors for development of B-CLL, while TAP2-665 AG heterozygous genotype may have a prognostic significance
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.He.A (Browse shelf(Opens below)) Not for loan 01010110070436000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.He.A (Browse shelf(Opens below)) 70436.CD Not for loan 01020110070436000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Transporter associated with antigen presenting (TAP) genes that localized in the major histocompatability complex (MHC) class II region are playing a key role in endogenous pathways for antigen presentation. Polymorphisms of these genes have been reported to be common in different types of cancer. In the present study, TAP2-565 and TAP2-665 polymorphisms were determined using a PCR-RFLP method in 50 patients with chronic lymphocytic leukemia (CLL) as well as 65 age and sex matched adults were enrolled as a control group. TAP2-565 GA heterozygous genotype was found in 9/50 (18%) patients with B-CLL in comparison to 6/65 (9.2%) of control group (P value =0.135). The heterozygous type GA was only significantly associated with low red blood cell count and high lymphocytic count among CLL cases. TAP2-665 AG heterozygous genotype was found in 25/50 (50%) of patients with B- CLL in comparison to 29/65 (44.6%) of control group (P value =0.350). There was also a significant association between heterozygous type AG and some laboratory findings of CLL patients such as low hemoglobin level, low red blood cell count and high lymphocytic count. We found significant association between this genotype and worse prognosis in CLL cases according to both Binet staging system and Rai staging systems (P values = 0.014,0.021) respectively. Our results indicated that TAP2 gene polymorphisms (TAP2-565, TAP2-665) have no role as risk factors for development of B-CLL, while TAP2-665 AG heterozygous genotype may have a prognostic significance

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