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Immunohistochemical expression of cyclin d1 and ki 67 in premalignant and malignant prostatic lesions / Maram Mostafa Ayoub ; Supervised Samia Mohamed Gabal , Samar Abdelmonem Elsheikh , Hala Mohamed Elhanbuli

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Maram Mostafa Ayoub , 2016Description: 132 P. : charts , facsimiles ; 25cmOther title:
  • تعبير مناعى هستوكيميائى لل (سيكلين د1و كى 67) فى مرض ما قبل السرطان وسرطان البروستاتا [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Materials and Methods: A total of 50 cases including 25 cases of prostatic carcinoma, 10 of PIN and 15 of BPH were studied.Tumor grade was determined according to Gleason{u2019}s grading system. Cyclin D1 and Ki 67 expressions were determined by IHC staining. {u2022}Results: In cancer Cyclin D1 was expressed in 23 of 25(92%) cases, in PIN it was expressed in 8 of 10 (80%) cases while in BPH it was expressed in only 3 of 15 (20%) cases.Ki 67 was expressed in 20 of 25 (80%) cancer cases, in PIN it was expressed in 7 of 10 (70%) cases while in BPH it was expressed in only 1 of 15 (6.7%) cases. Both Cyclin D1 and Ki 67 were significantly up regulated in cancer cases as compared to BPH cases (p< 0.001).No significant correlation was found between the intensity of Cyclin D1 expression and gleason score whereas a statistically significant correlation was observed between the intensity of Ki 67 expression and gleason score (P < 0.001).In our study a statistically significant positive correlation was observed between Cyclin D1 and Ki 67 expression in cancer group, PIN group and BPH group with p value 0.03, 0.001 and 0.04 respectively. {u2022}Conclusions: Cyclin D1 and Ki 67 may be helpful in distinguishing between BPH and carcinoma of the prostate. Cyclin D1 plays an important role in the pathogenesis and evolution of prostate cancer rather than the prognosis, thus Cyclin D1 is not a reliable prognostic factor in cancer prostate.Ki 67 can be used as a prognostic factor for prostatic carcinoma
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Ma.I (Browse shelf(Opens below)) Not for loan 01010110070515000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Ma.I (Browse shelf(Opens below)) 70515.CD Not for loan 01020110070515000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology

Materials and Methods: A total of 50 cases including 25 cases of prostatic carcinoma, 10 of PIN and 15 of BPH were studied.Tumor grade was determined according to Gleason{u2019}s grading system. Cyclin D1 and Ki 67 expressions were determined by IHC staining. {u2022}Results: In cancer Cyclin D1 was expressed in 23 of 25(92%) cases, in PIN it was expressed in 8 of 10 (80%) cases while in BPH it was expressed in only 3 of 15 (20%) cases.Ki 67 was expressed in 20 of 25 (80%) cancer cases, in PIN it was expressed in 7 of 10 (70%) cases while in BPH it was expressed in only 1 of 15 (6.7%) cases. Both Cyclin D1 and Ki 67 were significantly up regulated in cancer cases as compared to BPH cases (p< 0.001).No significant correlation was found between the intensity of Cyclin D1 expression and gleason score whereas a statistically significant correlation was observed between the intensity of Ki 67 expression and gleason score (P < 0.001).In our study a statistically significant positive correlation was observed between Cyclin D1 and Ki 67 expression in cancer group, PIN group and BPH group with p value 0.03, 0.001 and 0.04 respectively. {u2022}Conclusions: Cyclin D1 and Ki 67 may be helpful in distinguishing between BPH and carcinoma of the prostate. Cyclin D1 plays an important role in the pathogenesis and evolution of prostate cancer rather than the prognosis, thus Cyclin D1 is not a reliable prognostic factor in cancer prostate.Ki 67 can be used as a prognostic factor for prostatic carcinoma

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