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Study of the possible mechanism(s) involved in the experimentally induced systemic inflammatory response syndrome : Effects of different therapeutic strategies / Maha Adel Ahmed Rabie ; Supervised Sanaa A. Kenawy , Nihad I. Eid , Mohammed M. Nooh

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Maha Adel Ahmed Rabie , 2016Description: 167 P. : charts , facsimiles ; 25cmOther title:
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Lipopolysaccharide (LPS) is recognized by the innate immune system via Toll-Like Receptor 4 (TLR4) whose activation leads to the production of numerous immunoregulatory molecules and reactive oxygen species. This study was designed to investigate the effects of baicalin (TLR4-inhibitor) on LPS-induced renal oxidative and immunological changes of mice. Male Swiss mice were injected with LPS (1 mg/kg; i.p.) and the effects of pretreatment with TLR4 inhibitor (baicalin 50 mg/kg; i.p.) on LPS-induced renal failure and kidney pathology were examined 3 or 24 hours post LPS injection. Plasma concentrations of urea, creatinine and lactate dehydrogenase (LDH) activity as well as kidney content of interleukin-1Ý (IL-1Ý) and IL-10 were assessed. Oxidative stress as well as the RNA expression of neutrophil gelatinase-associated lipocalin (NGAL) and inhibitor of nuclear factor-kappa B (NF-mB) alpha (ImBÜ) in the kidney were also evaluated. LPS markedly increased plasma urea and creatinine levels as well as LDH activity. Furthermore, LPS augmented renal malondialdehyde and IL-10 levels as well as caspase-3 activity. However, it diminished the reduced glutathione and IL-1Ý levels; besides, it inhibited superoxide dismutase and catalase activities in the kidney. Histopathologic studies backed the previous observations. Baicalin pretreatment significantly ameliorated LPS-induced alterations and suppressed acute kidney injury (AKI) by modulating NGAL and ImB-Ü mRNA levels. In conclusion, the present study suggests that baicalin has potential beneficial role in sepsis prevention and its associated renal derangements
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2016.Ma.S (Browse shelf(Opens below)) Not for loan 01010110070607000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2016.Ma.S (Browse shelf(Opens below)) 70607.CD Not for loan 01020110070607000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Lipopolysaccharide (LPS) is recognized by the innate immune system via Toll-Like Receptor 4 (TLR4) whose activation leads to the production of numerous immunoregulatory molecules and reactive oxygen species. This study was designed to investigate the effects of baicalin (TLR4-inhibitor) on LPS-induced renal oxidative and immunological changes of mice. Male Swiss mice were injected with LPS (1 mg/kg; i.p.) and the effects of pretreatment with TLR4 inhibitor (baicalin 50 mg/kg; i.p.) on LPS-induced renal failure and kidney pathology were examined 3 or 24 hours post LPS injection. Plasma concentrations of urea, creatinine and lactate dehydrogenase (LDH) activity as well as kidney content of interleukin-1Ý (IL-1Ý) and IL-10 were assessed. Oxidative stress as well as the RNA expression of neutrophil gelatinase-associated lipocalin (NGAL) and inhibitor of nuclear factor-kappa B (NF-mB) alpha (ImBÜ) in the kidney were also evaluated. LPS markedly increased plasma urea and creatinine levels as well as LDH activity. Furthermore, LPS augmented renal malondialdehyde and IL-10 levels as well as caspase-3 activity. However, it diminished the reduced glutathione and IL-1Ý levels; besides, it inhibited superoxide dismutase and catalase activities in the kidney. Histopathologic studies backed the previous observations. Baicalin pretreatment significantly ameliorated LPS-induced alterations and suppressed acute kidney injury (AKI) by modulating NGAL and ImB-Ü mRNA levels. In conclusion, the present study suggests that baicalin has potential beneficial role in sepsis prevention and its associated renal derangements

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