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Infection in systemic lupus erythematosus (SLE) patients : Prevalence and risk factors / Shimaa Khaled Sayed ; Supervised Somaya Anwar Hussein , Dalia Ahmed Dorgham

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shimaa Khaled Sayed , 2016Description: 179 P. : charts , facsimiles ; 25cmOther title:
  • الانتشار وعوامل الخطر : العدوى فى مرضى الذئبة الحمراء [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation Summary: This work aimed to study the prevalence of infection in patients with systemic lupus erythematosus (SLE), find out the different predictors and risk factors for infection in SLE and to correlate infection with different clinical, laboratory parameters, disease activity scores and use of glucocorticoids and immunosuppressive drugs. One hundred patients with SLE, all fulfilling the 2012 SLICC criteria for the classification of SLE. All patients included in this study were subjected to full history taking, clinical examination, laboratory investigations as well as specific investigations directed to diagnosis of infection, its site and causative organism. Our results showed that the most common sites of infection in SLE patients were chest and skin, while the most common type of infectious organisms was bacteria. Younger age, early disease, cardiac and pulmonary involvement, high ESR, thrombocytopenia, elevated serum creatinine, elevated 24-hours urinary proteins, consumed C3 and C4, high systemic lupus erythematosus disease activity index (SLEDAI) score and use of cyclophosphamide (CYC), mycophenolate mofetil (MMF) and high dose of glucocorticoids (GC), all were associated with increased risk of infection in SLE patients. Hydroxychloroquine (HCQ) use was negatively associated with infection
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.M.Sc.2016.Sh.I (Browse shelf(Opens below)) Not for loan 01010110070504000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.M.Sc.2016.Sh.I (Browse shelf(Opens below)) 70504.CD Not for loan 01020110070504000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation

This work aimed to study the prevalence of infection in patients with systemic lupus erythematosus (SLE), find out the different predictors and risk factors for infection in SLE and to correlate infection with different clinical, laboratory parameters, disease activity scores and use of glucocorticoids and immunosuppressive drugs. One hundred patients with SLE, all fulfilling the 2012 SLICC criteria for the classification of SLE. All patients included in this study were subjected to full history taking, clinical examination, laboratory investigations as well as specific investigations directed to diagnosis of infection, its site and causative organism. Our results showed that the most common sites of infection in SLE patients were chest and skin, while the most common type of infectious organisms was bacteria. Younger age, early disease, cardiac and pulmonary involvement, high ESR, thrombocytopenia, elevated serum creatinine, elevated 24-hours urinary proteins, consumed C3 and C4, high systemic lupus erythematosus disease activity index (SLEDAI) score and use of cyclophosphamide (CYC), mycophenolate mofetil (MMF) and high dose of glucocorticoids (GC), all were associated with increased risk of infection in SLE patients. Hydroxychloroquine (HCQ) use was negatively associated with infection

Issued also as CD

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