header
Image from OpenLibrary

Evaluation of the potential protective effect of certain agents in cisplatin-induced testicular toxicity in male rats / Ahmed Hamdy Eid Elsayed ; Supervised Ezz Eldin S. Eldenshary , Bahia M. Elsayeh , Hala M. Fawzy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Hamdy Eid Elsayed , 2016Description: 157 P. : charts , facsimiles ; 25cmOther title:
  • {uFE97}{uFED8}{uFEF4}{uFEF4}{uFEE2} {uFE8D}{uFEDF}{uFE98}{uFE84}{uFE9B}{uFEF4}{uFEAE} {uFE8D}{uFEDF}{uFEEE}{uFED7}{uFE8E}{uFE8B}{uFEF0} {uFE8D}{uFEDF}{uFEE4}{uFEA4}{uFE98}{uFEE4}{uFEDE} {uFEDF}{uFE92}{uFECC}{uFEBE} {uFE8D}{uFEDF}{uFEE4}{uFEEE}{uFE8D}{uFEA9} {uFED3}{uFEF0} {uFE97}{uFEB4}{uFEE4}{uFEE2} {uFE8D}{uFEDF}{uFEA8}{uFEBC}ية {uئإ٨ؤ}{uئإؤئ}{uئإإ٤}{uئإء٤}{uئإءء}{uئإ٩٩} {uئإ٩١}{uئإإإ}{uئإ٨ؤ}{uئإآ٣}{uئإأ٤}{uئإ٩٤} {uئإأآ}{uئإؤ٨}{uئإ٨إ}{uئإءؤ} {uئإ٨ؤ}{uئإؤئ}{uئإآ٤}{uئإئ٤}{uئإآ٤}{uئإ٩٢}{uئإئأ}{uئإ٩٧}{uئإئ٤}{uئإإ٦} {uئإؤ٣}{uئإئ٠} {uئإءآ}{uئإؤآ}{uئإإإ}{uئإءؤ}{uئإ٨ؤ}{uئإؤئ}{uئإء٠}{uئإءإ}{uئإءآ}{uئإ٨ؤ}ن [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Drug-induced testicular toxicity is an extremely common condition and is responsible for a variety of pathological effects on the testes. Cisplatin (CIS), one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. Despite the prevalent clinical applications of cisplatin, serious toxic side effects comprising reproductive toxicity confine its therapeutic efficacy. The present study was performed to elucidate some of the mechanisms involved in the testicular protective effects of captopril (Cap), telmisartan (Tel), carvedilol (Car), and L-carnitine (L-car) in experimentally cisplatin-induced testicular toxicity in rats. Male adult Sprague Dawley rats were divided into (i) normal untreated rats, (ii) 0.5 % carboxymethyle cellulose (CMC) (10 ml/kg/day, p.o, 15 days) treated rats, (iii) CIS (10 mg/kg; i.p.) treated rats to serve as testicular toxic control group, (iv) Cap (100 mg/kg/day, p.o, 15 days) treated rats, (v) Tel (10 mg/kg/day, p.o, 15 days) treated rats, (vi) Car (10 mg/kg/day, p.o, 15 days) treated rats,(vii) L-car (500 mg/kg/day, i.p, 15 days) treated rats, (viii) Cap+CIS treated rats, (ix) Tel+CIS treated rats, (x) Car+CIS treated rats, (xi) L-car+CIS treated rats. Cisplatin prominently decreased reproductive organs weights, sperm count, sperm motility, and increased sperm abnormalities, along with histopathological damage of testicular tissues
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2016.Ah.E (Browse shelf(Opens below)) Not for loan 01010110070705000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2016.Ah.E (Browse shelf(Opens below)) 70705.CD Not for loan 01020110070705000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Drug-induced testicular toxicity is an extremely common condition and is responsible for a variety of pathological effects on the testes. Cisplatin (CIS), one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. Despite the prevalent clinical applications of cisplatin, serious toxic side effects comprising reproductive toxicity confine its therapeutic efficacy. The present study was performed to elucidate some of the mechanisms involved in the testicular protective effects of captopril (Cap), telmisartan (Tel), carvedilol (Car), and L-carnitine (L-car) in experimentally cisplatin-induced testicular toxicity in rats. Male adult Sprague Dawley rats were divided into (i) normal untreated rats, (ii) 0.5 % carboxymethyle cellulose (CMC) (10 ml/kg/day, p.o, 15 days) treated rats, (iii) CIS (10 mg/kg; i.p.) treated rats to serve as testicular toxic control group, (iv) Cap (100 mg/kg/day, p.o, 15 days) treated rats, (v) Tel (10 mg/kg/day, p.o, 15 days) treated rats, (vi) Car (10 mg/kg/day, p.o, 15 days) treated rats,(vii) L-car (500 mg/kg/day, i.p, 15 days) treated rats, (viii) Cap+CIS treated rats, (ix) Tel+CIS treated rats, (x) Car+CIS treated rats, (xi) L-car+CIS treated rats. Cisplatin prominently decreased reproductive organs weights, sperm count, sperm motility, and increased sperm abnormalities, along with histopathological damage of testicular tissues

Issued also as CD

There are no comments on this title.

to post a comment.