Histological and ultrastructural study of the chloropyrifos {u2013} induced pulmonary changes in male adult albino rat and the possible protective role of vitamin E / Mohamed Mohamed Abdelmoaty ; Supervised Ibrahim Labib Abdalla , Ehab Abdelaziz Ahmed Elshaarawy , Gamal Hosni Mohamed

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anatomy

Organophosphorus compounds are insecticides used in a wide scale for protection of crops and stored food products as well as maintaining and improving the public health through the control of vector borne diseases. In 1974, the use of these insecticides caused the death of thousands of living domestic animals. Hazards of pesticides are not limited to occupational incidents but also, to levels of these chemicals in food and environment. Since the use of chlorpyrifos as an effective insecticide in agriculture is wide, there is much interest for studying its harmful effects on different organs. The aim of this work was to study the effect of chlorpyrifos in (1/4 LD50) dose through different periods, histologically and ultrastructurally, on the lung and the protective role of vitamin E. The lung is considered as an important site for gas exchange and depends for its proper function upon the integrity of its histological components. In comparison with normal control group, oral administration of chlorpyrifos at (1/4 LD50) dose caused marked histopathological alterations of the lungs of the tested groups. The tested groups examined showed signs of the intoxicated lung in the form of destruction of the bronchioles and alveoli. Also, marked cellular infiltration, congestion of blood vessels and areas of necrosis in the lungs of the treated rats were observed. Co-administration of vitamin E made these histological alterations less obvious

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