New synthetic strategy for synthesis of novel bis-hetaryl ketones having expected biological activities / Waleed Ahmad Mahmoud Ahmad Elenany ; Supervised Ahmad S. Shawali , Abdou O. Abdelhamid , Sobhy M. Gomaa

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The original work of the submitted thesis consists of two research projects: In the first part: Sodium 1-aryl-3-(3-(ethoxycarbonyl)-5-methyl-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-olate was used as precursor for preparation of some novel derivatives of various fused heterocyclic ring systems namely azolotriazine, azinotriazine and azolopyridazine. The structures of the products isolated were established by their spectral data and elemental analyses. The antibacterial and antifungal activities of the new products were also evaluated. In the second part: New series of novel functionalized thiazoles, 1,3,4-thiadiazoles, pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidines and 1,3-thiazines containing pyrazole moiety were synthesized using 4-acetylpyrazole as a precursor. The structures of the compounds prepared were confirmed by both spectral and elemental analyses and by alternate synthesis. The mechanisms of the reactions studied were also discussed. The mechanisms of the studied reactions were also discussed. Sixteen compounds were evaluated for their in vitro antimicrobial activity. The results proclaimed that some of the tested compounds exhibited moderate to significant antibacterial and antifungal activities. Also, the anticancer activity of some other compounds has been evaluated

Issued also as CD