Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

In this study, the role of EUS in the assessment of patients referred with suspected submucosal tumours in the oesophagus, stomach or duodenum with negative endoscopic biopsies is evaluated, depending on the echocharacteristics of the lesion and the results of endosonography guided fine needle aspiration cytology or biopsy from the suspicious lesions and comparing there results with the final results that were achieved by one of three means; surgical or submucosal resection (SMR) (in those proved or suspected to be malignant), pathological confirmation in suspicious lesions by FNAC or regular follow up every 6 months for at least 18 months in cases with diagnostic EUS echocharacteristics of benign lesions. Benign nature of the lesion was confirmed by no or minimal increase in size & no change in the EUS features throughout this period. This study was conducted on 40 patients suffering from submucosal GIT masses (in the oesophagus, stomach or duodenum) with negative endoscopic biopsies; attending to the N.H.T.M.R.I to undergo EUS for further evaluation of their suspected submucosal masses. Those patients are either; accidentally discovered during endoscopy for other pathology, presenting with symptoms as hematemesis, dysphagia, and abdominal pain or presenting with abdominal mass by abdominal ultrasonography or CT

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