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Coordinating behavior of flubendazole and fenbendazole towards some transition metal ions / Eslam Mahmoud Abdelrahman Elbakry ; Supervised Nour Tawfik Abdelghani , Ahmed Moustafa Mansour

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eslam Mahmoud Abdelrahman Elbakry , 2016Description: 134 , 28 P. : charts , photographs ; 25cmOther title:
  • السلوك التناسقى للفلوبيندازول و الفينبندازول تجاه بعض أيونات الفلزات الانتقالية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry Summary: Flubendazole and Fenbendazole are well known benzimidazole carbamate drugs used in the treatment and prevention of several endoparasitic diseases in animals and humans. This work has been carried out to investigate the coordinating behavior of flubendazole and fenbendazole drugs towards some transition metal ions aiming to enhance their biological activity. The Pd (II) and Cu (II) complexes of Flubendazole with different anions have been synthesized and tested for their antibacterial and anticancer activities. Co (II), Ni (II) and Cu (II) complexes of fenbendazole have also been prepared and evaluated for their antibacterial activity. The complexes were characterized by elemental, IR, 1H-NMR, EPR, UV-Vis., magnetic, conductance measurements and thermal analyses. Geometry optimization, molecular electrostatic potential maps and natural bond orbital analysis were carried out using density functional theory. The biological activity is affected by the type of the coordinated or ionic anion
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.09.M.Sc.2016.Es.C (Browse shelf(Opens below)) Not for loan 01010110070777000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.09.M.Sc.2016.Es.C (Browse shelf(Opens below)) 70777.CD Not for loan 01020110070777000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry

Flubendazole and Fenbendazole are well known benzimidazole carbamate drugs used in the treatment and prevention of several endoparasitic diseases in animals and humans. This work has been carried out to investigate the coordinating behavior of flubendazole and fenbendazole drugs towards some transition metal ions aiming to enhance their biological activity. The Pd (II) and Cu (II) complexes of Flubendazole with different anions have been synthesized and tested for their antibacterial and anticancer activities. Co (II), Ni (II) and Cu (II) complexes of fenbendazole have also been prepared and evaluated for their antibacterial activity. The complexes were characterized by elemental, IR, 1H-NMR, EPR, UV-Vis., magnetic, conductance measurements and thermal analyses. Geometry optimization, molecular electrostatic potential maps and natural bond orbital analysis were carried out using density functional theory. The biological activity is affected by the type of the coordinated or ionic anion

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