Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applications in Environmental Photochemistry and Agriculture

This thesis mainly sought to produce and characterize a new ascorbic acid (AA) compound has a high stability profile. In addition, it investigated the cytotoxic effects and the proliferation rate of the synthesized composite on adult human dermal fibroblasts cells. It also sheds light on the immense therapeutic potential of AA as a free radical scavenger. For decades, it has been a common practice throughout the world to use AA in cosmetic preparations and skin care blends. Ascorbic acid has been extensively utilized for maintaining healthy resilient skin and treating hyperpigmentation. AA is essential for rebuilding skin collagen as it promotes collagen biosynthesis and generally functions as an antioxidant mitigates and neutralizes the effects of free radicals which are generating ubiquitous within our bodies by overexposure to UV radiation, environmental pollutants and stress. It also decreases hyperpigmentation because it is affecting the levels of glutathione which inhibits melanin production; it converts the inactive oxidized glutathione back to its active form. Despite all these benefits of AA, we claim that most of them have not been optimally exploited yet because AA associated with many problems such as its poor stability in air, light, and at high temperatures and its rapid decomposition into inactive compounds

Issued also as CD