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Clinical significance of protein Z and endothelin-1 genetic polymorphism in pediatric Egyptian sickle cell disease patients / Mahmoud Ali Mahmoud ; Supervised Mervat Mamdooh Khorshied , Nohair Soliman Mohamed , Mona Kamal Elghamrawy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mahmoud Ali Mahmoud , 2016Description: 161 P. : facsimiles ; 25cmOther title:
  • الأهمية الإكلينيكية للتعدد الشكلى لجينى البروتين زد و الإندوثيلين -1 فى الأطفال المصريين المصابين بأنيميا الخلايا المنجلية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Sickle cell disease (SCD) is a group of genetic disorders of hemoglobin that causes multisystem morbidity and an increase the risk of early death. The aim of the current study was to explore the possible association between genetic variation in protein ZG79A and Endothelin-1 G5665T genes and clinical and laboratory disease related variables in Egyptian sickle cell disease patients. To achieve our aim, genotyping of the two genes were performed by PCR- RFLP technique for 100 pediatric SCD patients and 100 age and gender matched healthy controls. The study revealed that the Protein ZG79A polymorphic genotypes (GA and AA) shows no statistically significant difference in the distribution of the polymorphic genotypes between SCD patients and the control Group. As regard the frequency of endothelin-1 G5665T polymorphic genotypes (GT and TT), statistical analysis revealed that there was no statistically significant difference in the distribution of the polymorphic genotypes between SCD patients and control group
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Ra.C (Browse shelf(Opens below)) Not for loan 01010110071018000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Ra.C (Browse shelf(Opens below)) 71018.CD Not for loan 01020110071018000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Sickle cell disease (SCD) is a group of genetic disorders of hemoglobin that causes multisystem morbidity and an increase the risk of early death. The aim of the current study was to explore the possible association between genetic variation in protein ZG79A and Endothelin-1 G5665T genes and clinical and laboratory disease related variables in Egyptian sickle cell disease patients. To achieve our aim, genotyping of the two genes were performed by PCR- RFLP technique for 100 pediatric SCD patients and 100 age and gender matched healthy controls. The study revealed that the Protein ZG79A polymorphic genotypes (GA and AA) shows no statistically significant difference in the distribution of the polymorphic genotypes between SCD patients and the control Group. As regard the frequency of endothelin-1 G5665T polymorphic genotypes (GT and TT), statistical analysis revealed that there was no statistically significant difference in the distribution of the polymorphic genotypes between SCD patients and control group

Issued also as CD

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