Hypertension in pediatric renal transplant recepients / Mohamed Sayed Ahmed Mohammed ; Supervised Fatina Ibrahim Fadel , Hafez Mahmoud Bazaraa , Doaa Mohammed Salah

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Hypertension is well known complications following kidney transplantation (Tx) in children having many pre and post transplantation risk factors and it is a major risk factor for atherosclerotic cardiovascular disease which is the leading cause of premature death and a major factor in graft failure in transplant recipients. We aimed to evaluate the prevalence, risk factors, and impact of hypertension on graft outcome in children post kidney transplantation. Data of fifty seven transplanted children was obtained and analyzed. Information was obtained from a questionnaire with the patients` guardians as well as review of medical record. Thirty six (63.1%) of the included cases were hypertensive on antihypertensive mediacations.There was statistically significant association between hypertension post Tx and pre Tx hypertension, hepatitis C viral infection, erythropoietin administration and renal artery RI of the study group (p = 0.001, 0.019, 0.041 and 0.021 respectively). No significant relation was found between post Tx hypertension and type of CNI, MMF or number of steroid pulses (P = 0.371, 0.360, 0.215 respectively). No statistical significant relation was found with number or type of acute rejection episodes (p = 0.172, 0.570 respectively). Significant association was found between post Tx hypertension and chronic graft nephropathy (IFTA) (p = 0.014)

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