Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

The aim of the present study was to evaluate the use of platelet rich fibrin and Nano-hydroxyapetite as a regenerative treatment in furcation class II defect.Material and methods Eight young adult dogs, with intact maxillary and mandibular teeth with good systemic and periodontal health will be selected for the study, In each dog 4 premolars will be included in the study (2 in each side) apart from each other and will be treated as follow: First will be treated with Nano hydroxyapatite alone Second will be treated with PRF alone Third will be treated with Nano hydroxyapatite and PRF Fourth will not receive any additional treatment than debridement (controls). Results In the present study, through histomorphometric analysis, the greatest value of area percent of newly formed bone was observed in the (PRF+ NHA bone) group, followed by the PRF group, then the NHA group, with the least value recorded in the control group. The difference was none statistically significant except in comparing (PRF+ NHA group) with control group (p<0.05). Conclusions The combined use of both PRF and Nano hydroxyapatite in treatment of periodontal furcation class II defects could accelerate healing processes getting use of the synergic effect of the powerful inherent regenerative potential of PRF and Nano hydroxyapatite

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