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Immunohistochemical study of galectin-3 expression in laryngeal squamous cell carcinoma / Wala{u2019}a Ahmad Alsayed Ashmawy ; Supervised Maha Mossad Mossad , Samar Abdelmonem Elsheikh , Amira Mohamed Bassam

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Wala{u2019}a Ahmad Alsayed Ashmawy , 2016Description: 103 P. : facsimiles ; 25cmOther title:
  • دراسة كيميائية هستومناعية لتعبير الجالاكتن-٣ فى سرطان الخلايا الحرشفية بالحنجرة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Galectin-3 is a 29-35 KDa chimaera-type galectin, which is normally expressed in various cells and tissues, and shows pleiotropic biological functions in cell growth and apoptosis. It is closely involved in tumor cell proliferation, transformation, migration, invasion and metastasis. The aim of this work is to evaluate the expression of galectin-3 in laryngeal squamous cell carcinoma and to correlate the expression of galectin-3 with available clinicopathological data. Forty total laryngectomy specimens; collected from the pathology department, Faculty of medicine, Cairo university. Two slides were prepared from each paraffin embedded tumor block, one slide for Hematoxylin and eosin staining and the other for immunohistochemically staining by galectin-3 monoclonal antibody. 34 cases (85%) showed positive Galectin-3 expression, and a statistically significant correlation was found between galectin-3 expression in normal, dysplastic epithelium / insitu component and the concomitant positive expression in the invasive malignant tumor tissue. However correlations between galectin-3 expression and available clinicopathological data were all non significant
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Wa.I (Browse shelf(Opens below)) Not for loan 01010110071122000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Wa.I (Browse shelf(Opens below)) 71122.CD Not for loan 01020110071122000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology

Galectin-3 is a 29-35 KDa chimaera-type galectin, which is normally expressed in various cells and tissues, and shows pleiotropic biological functions in cell growth and apoptosis. It is closely involved in tumor cell proliferation, transformation, migration, invasion and metastasis. The aim of this work is to evaluate the expression of galectin-3 in laryngeal squamous cell carcinoma and to correlate the expression of galectin-3 with available clinicopathological data. Forty total laryngectomy specimens; collected from the pathology department, Faculty of medicine, Cairo university. Two slides were prepared from each paraffin embedded tumor block, one slide for Hematoxylin and eosin staining and the other for immunohistochemically staining by galectin-3 monoclonal antibody. 34 cases (85%) showed positive Galectin-3 expression, and a statistically significant correlation was found between galectin-3 expression in normal, dysplastic epithelium / insitu component and the concomitant positive expression in the invasive malignant tumor tissue. However correlations between galectin-3 expression and available clinicopathological data were all non significant

Issued also as CD

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