Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Periodontal disease consists of various conditions that affect the soft and hard supporting structures surrounding the teeth that is caused by accumulation of dental plaque on the teeth, among the most common forms of periodontal disease is chronic periodontitis. Most tissue damage found in patients with periodontitis result from an exaggerated host immune response to bacterial challenges which results in the secretion of pro-inflammatory cytokines and enzymes that results in destruction of periodontal tissues. Prostanoids, including prostaglandins are bioactive lipid molecules derived from arachidonic acid of the membrane phospholipids in response to various stimuli, they have various important roles in physiological and pathological conditions. The levels of prostaglandin E2 (PGE2) in gingival crevicular fluid (GCF) have been reported to correlate positively with periodontal inflammation. Periodontal treatment including nonsurgical and surgical periodontal therapies. The key for success of periodontal therapy is the thorough mechanical debridement. Modified Widman Flap (MWF) is among the periodontal surgical techniques for treatment of chronic periodontitis used for pocket elimination. Nutrition plays a great role in improving the person quality of life, for example Omega -3 PUFA has a well-established anti-inflammatory role in periodontal disease. Adequate dietary intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs) resulted in increases tissue concentration of the types of fatty acids(e.g., eicosapentaenoic acid and docosahexaenoic acid) that downregulate inflammation, Omega-3(n-3) PUFA have multiple actions by which they can affect cell and tissue behavior to perform their physiological actions. This study was undertaken to evaluate the effects of omega-3 fatty acids supplementation after modified widman periodontal flap surgery on clinical parameters and gingival crevicular fluid (GCF) levels of prostaglandin E2 (PGE2)

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