Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Repaglinide is a fast acting insulinotropic agent with an insulin release profile that mimics that of physiological glucose-stimulated insulin release. It is used in the manage»ment of type 2 diabetes, controlling both postprandial blood glucose (BG) and fasting BG levels, thereby minimizing the risk of diabetes-associated complications. In this study, we selected repaglinide as a model drug due to its pH dependent poor aqueous solubility. Chapter Ї modification of solubility and dissolution profile of Repaglinide by using vesicle system. The aim of the work in this chapter was to formulate niosomes loaded with repaglinide and to evaluate the prepared formulations in order to choose the best achieved formula for further studies. Chapter ЇЇ modification of solubility and dissolution profile of repaglinide by using solid dispersion technique. The aim of the work in this chapter was to formulate solid dispersion of RPG and to evaluate the prepared formulations in order to choose the best achieved formula to improve the oral bioavailability of the drug and to obtain burst release of RPG. Chapter ЇЇЇ preparation and evaluation of oral disintegrating tablet of repaglinide as a single dose therapy. The aim of the work in this chapter was to formulate oral disintegrating tablets as a single dose therapy from the selected best achieved formulae

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