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Comparative studies on hepatoprotective agents in rats / Zeinab Adel Mahmoud Elgendy ; Supervised Salah Eldin Abdelhamid Mohamed Youssef , Amer Ramadan Ali Ayad , Seham Abdelsatar Elbatran

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Zeinab Adel Mahmoud Elgendy , 2016Description: 187 P. : photographs ; 25cmOther title:
  • دراسة مقارنة للعوامل ذات التاثير الوقائى للكبد فى الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology Summary: This study was designed to investigate the hepatoprotective and antioxidant activities of omega-3, l- carnitine, vitamin c and their combination against acetaminophen-induced hepatotoxicity in rats. Rats were pretreated with omega-3, l-carnitine, vitamin c and their combination for twenty-one days prior to oral ingestion of acetaminophen. Then rats received a single toxic dose of acetaminophen. The obtained results showed that pretreatment with omega-3, l- carnitine, vitamin c and their combination limited the toxic effects of acetaminophen. This study concluded that animals treated with the combination (25 OLV) [25 mg / kg b.wt. p.o. Omega-3 plus 50 mg/kg b.wt. p.o. L- carnitine plus 100 mg / kg b.wt. p.o. Vitamin-C] showed the highest hepatoprotective activity against experimentally induced hepatotoxicity in rats. That appeared in most performed tests ALT, AST, Cholesterol, HDL- cholesterol, LDL- cholesterol, Il-6, TNF-Ü, MDA, NOX, GSH, FTIR, Histopathology and Immunohistochemistry caspase-3 and Bax
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.M.Sc.2016.Ze.C (Browse shelf(Opens below)) Not for loan 01010110071172000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.M.Sc.2016.Ze.C (Browse shelf(Opens below)) 71172.CD Not for loan 01020110071172000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

This study was designed to investigate the hepatoprotective and antioxidant activities of omega-3, l- carnitine, vitamin c and their combination against acetaminophen-induced hepatotoxicity in rats. Rats were pretreated with omega-3, l-carnitine, vitamin c and their combination for twenty-one days prior to oral ingestion of acetaminophen. Then rats received a single toxic dose of acetaminophen. The obtained results showed that pretreatment with omega-3, l- carnitine, vitamin c and their combination limited the toxic effects of acetaminophen. This study concluded that animals treated with the combination (25 OLV) [25 mg / kg b.wt. p.o. Omega-3 plus 50 mg/kg b.wt. p.o. L- carnitine plus 100 mg / kg b.wt. p.o. Vitamin-C] showed the highest hepatoprotective activity against experimentally induced hepatotoxicity in rats. That appeared in most performed tests ALT, AST, Cholesterol, HDL- cholesterol, LDL- cholesterol, Il-6, TNF-Ü, MDA, NOX, GSH, FTIR, Histopathology and Immunohistochemistry caspase-3 and Bax

Issued also as CD

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