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Treatment of atrophic acne scars using platelet-rich plasma versus combined use of subcision and platelet-rich plasma : A comparative clinical study / Sammar Hassan Abdallah ; Supervised Akmal Saad Hassan , Marwa Safwat Elhawary , Heba Mohammed Abdelraheem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sammar Hassan Abdallah , 2016Description: 116 P. : charts , facsimiles ; 25cmOther title:
  • علاج ندبات حب الشباب الضامرة باستخدام البلازما الغنية بالصفائح الدموية مقارنة باستخدام القطع التحتى مع البلازما الغنية بالصفائح الدموية : دراسة مقارنة اكلينيكية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Summary: Background: Treatment of acne scars is still a challenge. Autologous Platelet rich plasma (PRP) is a safe and rich medium of growth factors and cytokines which serve in replenishing the lost collagen and elastic fibers. Subcision, also called as subcutaneous incisionless surgery, breaks the fibrotic strands, which tether the scar to the underlying subcutaneous tissue. The depression is lifted by the releasing action of the procedure, as well as from connective tissue that forms during the course of normal wound healing.Objectives: The aim of this study is to evaluate the efficacy of PRP as a monotherapy in treatment of atrophic acne scars and to compare it with the combined use of PRP and subcision in a prospective split-face, clinical study.Patients and methods: 30 patients with bilateral atrophic acne scars were enrolled. Each patient received 3 sessions with one month interval .The right side was treated with PRP alone and the left side received combined therapy with subcision and PRP simultaneously. Evaluation of response was done by comparing patient{u2019}s photos 3 months and 6 months following the last session.Results: Combined treatment with Subcision and PRP showed better results at 6 months, although a non statistical significant difference was detected when comparing the percentage of improvement after 3 and 6 months (p = 0.073). PRP alone showed a statistical significant difference when comparing the percentage of improvement after 3 and 6 months (p =0.046).On comparing both sides a non statistical significant difference was found but better improvement occurred with PRP alone at 3 months and 6 months.Conclusion: PRP monotherapy resulted in better overall scar improvement than combined Subcision and PRP therapy with significant lesser side effects and better patients satisfaction. This effect was evident three months and six months after end of therapy
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2016.Sa.T (Browse shelf(Opens below)) Not for loan 01010110070923000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2016.Sa.T (Browse shelf(Opens below)) 70923.CD Not for loan 01020110070923000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background: Treatment of acne scars is still a challenge. Autologous Platelet rich plasma (PRP) is a safe and rich medium of growth factors and cytokines which serve in replenishing the lost collagen and elastic fibers. Subcision, also called as subcutaneous incisionless surgery, breaks the fibrotic strands, which tether the scar to the underlying subcutaneous tissue. The depression is lifted by the releasing action of the procedure, as well as from connective tissue that forms during the course of normal wound healing.Objectives: The aim of this study is to evaluate the efficacy of PRP as a monotherapy in treatment of atrophic acne scars and to compare it with the combined use of PRP and subcision in a prospective split-face, clinical study.Patients and methods: 30 patients with bilateral atrophic acne scars were enrolled. Each patient received 3 sessions with one month interval .The right side was treated with PRP alone and the left side received combined therapy with subcision and PRP simultaneously. Evaluation of response was done by comparing patient{u2019}s photos 3 months and 6 months following the last session.Results: Combined treatment with Subcision and PRP showed better results at 6 months, although a non statistical significant difference was detected when comparing the percentage of improvement after 3 and 6 months (p = 0.073). PRP alone showed a statistical significant difference when comparing the percentage of improvement after 3 and 6 months (p =0.046).On comparing both sides a non statistical significant difference was found but better improvement occurred with PRP alone at 3 months and 6 months.Conclusion: PRP monotherapy resulted in better overall scar improvement than combined Subcision and PRP therapy with significant lesser side effects and better patients satisfaction. This effect was evident three months and six months after end of therapy

Issued also as CD

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